Alpha-lipoic acid has been described as the “antioxidant of antioxidants,” yet its clinical impact extends well beyond redox support. In this Professional Education Series episode, Emma Van Den Driest explores its unique biochemistry — including isomer forms, oxidised and reduced states, mitochondrial actions, and its ability to regenerate vitamin C, vitamin E and glutathione — alongside its effects on NF-κB signalling, insulin sensitivity and endothelial function.

Emma then translates these mechanisms into practice, reviewing evidence across metabolic dysfunction, PCOS, neuropathy, neurodegeneration, fertility, sensory conditions and more, to equip clinicians to prescribe alpha-lipoic acid with greater clarity and confidence.