Nathan Rose deep dives into Specialised Pro-Resolving Mediators (SPMs)—bioactive lipid mediators derived from omega-3 fatty acids that play a critical role in resolving inflammation. He explores their mechanism of action, including how they actively promote the resolution phase of inflammation without suppressing the immune response. He also discusses the clinical applications of SPMs, highlighting conditions where they offer significant therapeutic benefits. Additionally, he helps practitioners differentiate when to use SPMs over traditional fish oil, offering guidance on which patients would benefit from which supplement.