In this video, Emma Van Den Driest explores premenstrual dysphoric disorder (PMDD) through a multifaceted lens, beginning with its societal and historical context. She distinguishes PMDD from premenstrual syndrome (PMS) and premenstrual exacerbation (PME), shedding light on their diagnostic and clinical nuances. The pathophysiology is also examined and the neurometabolite-neurotransmitter interactions that contribute to PMDD are explored. Emma then discusses key herbs and nutrients to support patients with this complex and challenging disorder.