Cofactors and micronutrients to relieve and support energy

Generating energy from the food we eat requires several micronutrients as cofactors to make adenosine triphosphate (ATP), an energy-carrying molecule found in the cells of all living things, that powers cellular activities. The main site of ATP production is the mitochondria and as such, supporting these powerhouses is of immense value, especially in low energy states and chronic illness.1

Resveratrol is a polyphenolic flavonoid found in many plants, with potent antioxidant activity that helps to reduce levels of oxidative damage caused by free radicals. The mitochondria are susceptible to oxidative stress, which can underpin a number of chronic illnesses. Offsetting this damage is important for good health.3 

Resveratrol also activates sirtuin, a molecule involved in many physiological processes, particularly metabolic regulation, healthy aging and fatigue.3 Resveratrol is indicated to support anti-aging and chronic disease states especially where mitochondrial dysfunction is associated, but also metabolic and oxidative stress are at play.4

Nicotinamide or vitamin B3 helps in energy metabolism by supporting the synthesis of nicotinamide adenine dinucleotide (NAD+) in the mitochondria, a key co-enzyme in the generation of mitochondrial energy production.1 NAD+ not only supports energy production from food sources, it also activates sirtuins, thus helping to support healthy aging and mitochondrial health.2

Combining key cofactors that support energy production and regulation -- vitamin B3 and resveratrol -- is a great way to improve cellular health, restore energy levels, and reduce ageing.

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1. Huskisson E, Maggini S, Ruf M. The role of vitamins and minerals in energy metabolism and well-being. J Int Med Res. 2007 May-Jun;35(3):277-89.

2. Gropper SS & Smith JL. Advanced Nutrition and Human Metabolism. 6th Edition. Wadsworth CENGAGE Learning, Australia, 2013.

3. Nogueiras R, Habegger KM, Chaudhary N, Finan B, Banks AS, Dietrich MO, Horvath TL, Sinclair DA, Pfluger PT, Tschöp MH. Sirtuin 1 and sirtuin 3: physiological modulators of metabolism. Physiol. Rev. 2012 Jul;92(3):1479-514. doi: 10.1152/physrev.00022.2011. PMID: 22811431; PMCID: PMC3746174.

4. Schlenker ED, Long S. William’s Essentials of Nutrition & Diet Therapy. 9th Edition, Mosby Elsevier, Canada, 2007, p.218-219.

This post is educational content for practitioners only. 

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