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References - Nutritional, antioxidant & herbal support for musculoskeletal conditions

  1. Australian Institute of Health and Welfare, The burden of musculoskeletal conditions in Australia: a detailed analysis of the Australian Burden of Disease Study 2011. 2017, AIHW: Canberra. https://www.aihw.gov.au/getmedia/eed9f208-1d28-439c-aeb8-93509641fc72/20908.pdf.aspx?inline=true
  2. Campagne, D. Overview of Sprains and Other Soft-Tissue Injuries. 2017. https://www.aihw.gov.au/getmedia/eed9f208-1d28-439c-aeb8-93509641fc72/20908.pdf.aspx?inline=true
  3. Shaw, G., et al., Vitamin C-enriched gelatin supplementation before intermittent activity augments collagen synthesis. Am J Clin Nutr, 2017. 105(1): p. 136-143. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5183725/
  4. Chen, L., et al., Inflammatory responses and inflammation-associated diseases in organs. Oncotarget, 2018. 9(6): p. 7204-7218. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5805548/
  5. Guyton, A.C. and J.E. Hall, Textbook of Medical Physiology. 10th ed, ed. W.B. Saunders. 2000, Philadelphia.
  6. Alessandri, A.L., et al., Resolution of inflammation: mechanisms and opportunity for drug development. Pharmacol Ther, 2013. 139(2): p. 189-212. https://pubmed.ncbi.nlm.nih.gov/23583354/
  7. Gallo, J., et al., Inflammation and its resolution and the musculoskeletal system. Journal of orthopaedic translation, 2017. 10: p. 52-67. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5541893/
  8. Wongrakpanich, S., et al., A Comprehensive Review of Non-Steroidal Anti-Inflammatory Drug Use in The Elderly. Aging and disease, 2018. 9(1): p. 143-150. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5772852/
  9. Zimmerman, M., Burgerstein’s Handbook of Clinical Nutrition. Micronutrients in the Prevention and Therapy of Disease. 2001, Stuttgart: Thieme.
  10. Sophia Fox, A.J., A. Bedi, and S.A. Rodeo, The Basic Science of Articular Cartilage: Structure, Composition, and Function. Sports Health, 2009. 1(6): p. 461-468. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5772852/
  11. Pittman, R.N., The Circulatory System and Oxygen Transport, in Regulation of Tissue Oxygenation. 2011, Morgan & Claypool Life Sciences: San Rafael (CA).
  12. Kim, J. and W.Y. So, Effects of acute grape seed extract supplementation on muscle damage after eccentric exercise: A randomized, controlled clinical trial. Journal of Exercise Science and Fitness, 2019. 17(2): p. 77-79. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449740/
  13. Gabetta, B., et al., Characterization of proanthocyanidins from grape seeds. Fitoterapia, 2000. 71(2): p. 162-75. https://pubmed.ncbi.nlm.nih.gov/10727813/
  14. Ma, Z.F. and H. Zhang, Phytochemical Constituents, Health Benefits, and Industrial Applications of Grape Seeds: A Mini-Review. Antioxidants (Basel), 2017. 6(3):71. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5618099
  15. Robert, A.M., et al., Effect of procyanidolic oligomers on corneal collagen of rabbits treated by excimer laser photoablation. Biomed Pharmacother, 2006. 60(3): p. 113-20. https://www.ncbi.nlm.nih.gov/pubmed/16546347
  16. Schwitters, B., OPC in Practice. 2nd ed. 1995, Rome: Alfa Omega Editrice.
  17. Shimoi, K., et al., Radioprotective effect of antioxidative flavonoids in gamma-ray irradiated mice. Carcinogenesis, 1994. 15(11): p. 2669-72. https://www.ncbi.nlm.nih.gov/pubmed/7955124
  18. Connolly, D.A.J., M.P. McHugh, and O.I. Padilla-Zakour, Efficacy of a tart cherry juice blend in preventing the symptoms of muscle damage. British Journal Of Sports Medicine, 2006. 40(8): p. 679-83. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2579450/
  19. Trombold, J.R., et al., Ellagitannin consumption improves strength recovery 2-3 d after eccentric exercise. Med Sci Sports Exerc, 2010. 42(3): p. 493-8. https://www.ncbi.nlm.nih.gov/pubmed/19952825
  20. Djordjevic, D., et al., The influence of training status on oxidative stress in young male handball players. Mol Cell Biochem, 2011. 351(1-2): p. 251-9. https://www.ncbi.nlm.nih.gov/pubmed/21264496
  21. Finaud, J., G. Lac, and E. Filaire, Oxidative stress : relationship with exercise and training. Sports Med, 2006. 36(4): p. 327-58. https://www.ncbi.nlm.nih.gov/pubmed/16573358
  22. Taghizadeh, M., et al., Grape Seed Extract Supplementation and the Effects on the Biomarkers of Oxidative Stress and Metabolic Profiles in Female Volleyball Players: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. Iranian Red Crescent Medical Journal, 2016. 18(9): p. e31314. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5253210/
  23. Kim, J.K., et al., Grape Seed Extract Supplementation Attenuates the Blood Pressure Response to Exercise in Prehypertensive Men. J Med Food, 2018. 21(5): p. 445-453. https://www.ncbi.nlm.nih.gov/pubmed/29683391
  24. Beylot, C. and P. Bioulac, Therapeutic trial of a peripheral angioprotector, endotelon. Gaz Med Franc, 1980. 87(22): p. 2929.
  25. Dubos, G., G. Durst, and R. Hugonet, Evolution of capillary resistance, whether it be spontaneously or artificially diminished by the action of a capillaro-toxic substance in elderly persons. The beneficial action of endotelon on microcirculation. Rev Geriatrie, 1980. 5(6): p. 302-305.
  26. Dartenuc, J.Y., P. Marache, and H. Choussat, Capillary resistance in geriatrics – trial of a microvascular protective agent endotelon. Bordeaux Med, 1980. 13(18): p. 903-907.
  27. Lagrue, G., F. Olivier-Martin, and A. Grillot, [A study of the effects of procyanidol oligomers on capillary resistance in hypertension and in certain nephropathies (author's transl)]. Sem Hop, 1981. 57(33-36): p. 1399-401. https://www.ncbi.nlm.nih.gov/pubmed/6270799
  28. Costantini, A., T. De Bernardi, and A. Gotti, Clinical and capillaroscopic evaluation of chronic uncomplicated venous insufficiency with procyanidins extracted from vitis vinifera. Minerva Cardioangiol, 1999. 47(1-2): p. 39-46. https://www.ncbi.nlm.nih.gov/pubmed/10356940
  29. Delacroix, P., Double-blind trial of endotelon in chronic venous insufficiency. Rev Med, 1981. 22(27-28): p. 1793-1802.
  30. Vérin, P.H., A. Vildy, and J.F. Maurin, Retinopathy and OPC. Bordeaux Med, 1978. 11(16): p. 1467-1474.
  31. Fromantin, M., OPC in the treatment of capillary weakness and retinopathy in diabetics. Med Intern, 1981. 16(11): p. 432-434.
  32. Arne, J.L., Contribution to the study of procyanidolic oligomers: Endotelon in diabetic retinopathy (based on 30 cases). Gazette Médicale de France, 1982. 89(30): p. 3610-3614.
  33. Sarrat, L., Therapeutic relief of functional problems of the lower legs by Endotelon, a microangrioprotector. Bordeaux Médical, 1981. 14: p. 685-688.
  34. Royer, R.J. and C.L. Schmidt, Evaluation of venotropic drugs by venous gas plethsymograhy. A study of proanthocyanidolic oligomers. Sem Hop, 1981. 57(47-48): p. 2009-2013. https://www.ncbi.nlm.nih.gov/pubmed/6276983
  35. Belcaro, G., et al., Grape seed procyanidins in pre- and mild hypertension: a registry study. Evid Based Complement Alternat Med, 2013. 2013: p. 313142. https://www.researchgate.net/profile/Beatrice_Feragalli2/publication/258148674_Grape_Seed_Procyanidins_in_Pre-_and_Mild_Hypertension_A_Registry_Study/links/00b7d5315a52ad3550000000/Grape-Seed-Procyanidins-in-Pre-and-Mild-Hypertension-A-Registry-Study.pdf?origin=publication_detail
  36. Sano, A., S. Tokutake, and A. Seo, Proanthocyanidin-rich grape seed extract reduces leg swelling in healthy women during prolonged sitting. J Sci Food Agric, 2013. 93(3): p. 457-62. https://www.ncbi.nlm.nih.gov/pubmed/22752876
  37. Robinson, M., et al., Effect of Grape Seed Extract on Blood Pressure in Subjects with Pre-hypertension. Journal of Pharmacy and Nutrition Sciences, 2012. 2: p. 155-159. https://www.polyphenolics.com/wp-content/uploads/2014/10/3-BP-Effect-of-GSE-in-PreHyp-Journ-Pharm-Nutrit-2012.pdf
  38. Sivaprakasapillai, B., et al., Effect of grape seed extract on blood pressure in subjects with the metabolic syndrome. Metabolism, 2009. 58(12): p. 1743-6. https://www.ncbi.nlm.nih.gov/pubmed/19608210
  39. Terauchi, M., et al., Effects of grape seed proanthocyanidin extract on menopausal symptoms, body composition, and cardiovascular parameters in middle-aged women: a randomized, double-blind, placebo-controlled pilot study. Menopause, 2014. 21(9): p. 990-6. https://www.ncbi.nlm.nih.gov/pubmed/24518152
  40. Nadkarni, A., Dr K.M. Nadkarni’s Indian Materia Medica. 3rd ed. Popular Prakashan. Vol. 1. 1976, Bombay, India: First published 1954, reprinted Popular Prakashan.
  41. Frawley, D. and V. Lad, The Yoga of Herbs: An Ayurvedic Guide to Herbal Medicine. 2nd ed. 1988, Santa Fe: Lotus Press.
  42. Mills, S., The Essential Book of Herbal Medicine. 1991, London: Penguin Arkana.
  43. Grzanna, R., L. Lindmark, and C.G. Frondoza, Ginger--an herbal medicinal product with broad anti-inflammatory actions. J Med Food, 2005. 8(2): p. 125-32. https://www.ncbi.nlm.nih.gov/pubmed/16117603
  44. Martel-Pelletier, J., et al., Therapeutic role of dual inhibitors of 5-LOX and COX, selective and non-selective non-steroidal anti-inflammatory drugs. Annals Of The Rheumatic Diseases, 2003. 62(6): p. 501-509. https://www.ncbi.nlm.nih.gov/pubmed/16117603
  45. van Breemen, R.B., Y. Tao, and W. Li, Cyclooxygenase-2 inhibitors in ginger (Zingiber officinale). Fitoterapia, 2011. 82(1): p. 38-43. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3018740/
  46. Terry, R., et al., The use of ginger (Zingiber officinale) for the treatment of pain: a systematic review of clinical trials. Pain Med, 2011. 12(12): p. 1808-18. https://www.ncbi.nlm.nih.gov/pubmed/22054010
  47. Li, X.H., et al., Attenuation of liver pro-inflammatory responses by Zingiber officinale via inhibition of NF-kappa B activation in high-fat diet-fed rats. Basic Clin Pharmacol Toxicol, 2012. 110(3): p. 238-44. https://www.ncbi.nlm.nih.gov/pubmed/21902812
  48. Ziltener, J.L., S. Leal, and P.E. Fournier, Non-steroidal anti-inflammatory drugs for athletes: An update. Annals of Physical and Rehabilitation Medicine, 2010. 53(4): p. 278-288. https://www.ncbi.nlm.nih.gov/pubmed/20363203
  49. Wilson, P.B., Ginger (Zingiber officinale) as an Analgesic and Ergogenic Aid in Sport: A Systemic Review. Journal of strength and conditioning research, 2015. 29(10): p. 2980-95. https://www.ncbi.nlm.nih.gov/pubmed/20363203
  50. Zehsaz, F., N. Farhangi, and L. Mirheidari, The effect of Zingiber officinale R. rhizomes (ginger) on plasma pro-inflammatory cytokine levels in well-trained male endurance runners. Cent Eur J Immunol, 2014. 39(2): p. 174-80. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4440027/
  51. Black, C.D. and P.J. Oconnor, Acute effects of dietary ginger on quadriceps muscle pain during moderate-intensity cycling exercise. International Journal of Sport Nutrition and Exercise Metabolism, 2008. 18(6): p. 653-64. [Abstracthttps://www.ncbi.nlm.nih.gov/pubmed/19164834]
  52. Black, C.D. and P.J. O'Connor, Acute effects of dietary ginger on muscle pain induced by eccentric exercise. Phytotherapy Research, 2010. 24(11): p. 1620-6. [https://www.ncbi.nlm.nih.gov/pubmed/21031618]
  53. Black, C.D., et al., Ginger (Zingiber officinale) reduces muscle pain caused by eccentric exercise. J Pain, 2010. 11(9): p. 894-903. [https://www.ncbi.nlm.nih.gov/pubmed/20418184]
  54. Wilson, P.B., A Randomized Double-Blind Trial of Ginger Root for Reducing Muscle Soreness and Improving Physical Performance Recovery Among Experienced Recreational Distance Runners. Journal of Dietary Supplements, 2018: p. [Ahead of Print]. [https://www.ncbi.nlm.nih.gov/pubmed/30299178]
  55. Wilson, P.B., et al., Effectiveness of ginger root (Zingiber officinale) on running-induced muscle soreness and function: A pilot study. International Journal of Athletic Therapy and Training, 2015. 20(6): p. 44-50. [https://pdfs.semanticscholar.org/1c90/61cc5ea79ebc411b0383e498798bbdf68b18.pdf]
  56. Srivastava, K.C. and T. Mustafa, Ginger (Zingiber officinale) in rheumatism and musculoskeletal disorders. Med Hypotheses, 1992. 39(4): p. 342-8. [https://www.ncbi.nlm.nih.gov/pubmed/1494322]
  57. Haghighi, A., N. Tavalaei, and M. Owlia, Effects of ginger on primary knee osteoarthritis. Indian Journal of Rheumatology, 2006. 1(1): p. 3-7. [http://www.indianjrheumatol.com/temp/IndianJRheumatol113-413566_000653.pdf]
  58. Haghighi, M., et al., Comparing the effects of ginger (Zingiber officinale) extract and Ibuprofen on patients with osteoarthritis. Archives of Iranian medicine, 2005. 8(4): p. 267-271. [https://www.researchgate.net/profile/Masoud_Haghighi4/publication/235007127_Comparing_the_Effects_of_ginger_Zingiber_officinale_extract_and_ibuprofen_On_patients_with_osteoarthritis/links/5614835c08ae983c1b409703/Comparing-the-Effects-of-ginger-Zingiber-officinale-extract-and-ibuprofen-On-patients-with-osteoarthritis.pdf?origin=publication_detail]
  59. Niempoog, S., K.K. Pawa, and C. Amatyakul, The efficacy of powdered ginger in osteoarthritis of the knee. J Med Assoc Thai, 2012. 95(Suppl 1): p. S59-64. [https://www.ncbi.nlm.nih.gov/pubmed/23964445]
  60. Zakeri, Z., et al., Evaluating the effects of ginger extract on knee pain, stiffness and difficulty in patients with knee osteoarthritis. Journal of Medicinal Plants Research, 2011. 5(15): p. 3375-3379. [https://academicjournals.org/article/article1380629850_Zakeri%20et%20al.pdf]
  61. Haghighi, M., A. Khalvat, and T. Toliyat, Drug plants III. 2010, Houston: Studium Press LLC.
  62. Alipour, Z., et al., The Effect of Ginger on Pain and Satisfaction of Patients with Knee Osteoarthritis. Jundishapur Journal of Chronic Disease Care, 2017. 6(1): p. e34798. [http://jjchronic.com/en/articles/13625.html]
  63. Naderi, Z., et al., Effect of ginger powder supplementation on nitric oxide and C-reactive protein in elderly knee osteoarthritis patients: A 12-week double-blind randomized placebo-controlled clinical trial. J Tradit Complement Med, 2016. 6(3): p. 199-203. [http://jjchronic.com/en/articles/13625.html]
  64. Mozaffari-Khosravi, H., et al., Effect of Ginger Supplementation on Proinflammatory Cytokines in Older Patients with Osteoarthritis: Outcomes of a Randomized Controlled Clinical Trial. J Nutr Gerontol Geriatr, 2016. 35(3): p. 209-18. [https://www.ncbi.nlm.nih.gov/pubmed/27559855]
  65. Ozgoli, G., M. Goli, and F. Moattar, Comparison of effects of ginger, mefenamic acid, and ibuprofen on pain in women with primary dysmenorrhea. J Altern Complement Med, 2009. 15(2): p. 129-32. [https://www.ncbi.nlm.nih.gov/pubmed/19216660]
  66. Shirvani, M.A., N. Motahari-Tabari, and A. Alipour, The effect of mefenamic acid and ginger on pain relief in primary dysmenorrhea: a randomized clinical trial. Archives of Gynecology and Obstetrics, 2015. 291(6): p. 1277-1281. [https://www.ncbi.nlm.nih.gov/pubmed/25399316]
  67. Kashefi, F., et al., Comparison of the effect of ginger and zinc sulfate on primary dysmenorrhea: a placebo-controlled randomized trial. Pain Management Nursing, 2014. 15(4): p. 826-33. [https://www.ncbi.nlm.nih.gov/pubmed/24559600]
  68. Kocak, I., C. Yucepur, and O. Gokler, Is Ginger Effective in Reducing Post-tonsillectomy Morbidity? A Prospective Randomised Clinical Trial. Clin Exp Otorhinolaryngol, 2018. 11(1): p. 65-70. [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5831658/]
  69. Rayati, F., F. Hajmanouchehri, and E. Najafi, Comparison of anti-inflammatory and analgesic effects of Ginger powder and Ibuprofen in postsurgical pain model: A randomized, double-blind, case-control clinical trial. Dent Res J (Isfahan), 2017. 14(1): p. 1-7. [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356382/]
  70. Atashak, S., et al., Obesity-related cardiovascular risk factors after long- term resistance training and ginger supplementation. Journal of Sports Science & Medicine, 2011. 10(4): p. 685-691. [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3761505/]
  71. Hale, L.P., et al., Proteinase activity and stability of natural bromelain preparations. Int Immunopharmacol, 2005. 5(4): p. 783-93. [https://www.ncbi.nlm.nih.gov/pubmed/15710346]
  72. Orsini, R.A. and C. Plastic Surgery Educational Foundation Technology Assessment, Bromelain. Plast Reconstr Surg, 2006. 118(7): p. 1640-4. [https://www.ncbi.nlm.nih.gov/pubmed/17102739]
  73. Blumenthal, M., The Complete German Commission E monographs: Therapeutic Guide to Herbal Medicines. 1998.
  74. Maurer, H., Bromelain: biochemistry, pharmacology and medical use. Cell Mol Life Sci, 2001. 58(9): p. 1234-1245. [https://www.ncbi.nlm.nih.gov/pubmed/11577981]
  75. Rathnavelu, V., et al., Potential role of bromelain in clinical and therapeutic applications. Biomed Rep, 2016. 5(3): p. 283-288. [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4998156/]
  76. Pavan, R., et al., Properties and Therapeutic Application of Bromelain: A Review. Biotechnology Research International, 2012. 2012: p. 976203. [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3529416/]
  77. Roxas, M., The role of enzyme supplementation in digestive disorders. Altern Med Rev, 2008. 13(4): p. 307-14. [https://www.ncbi.nlm.nih.gov/pubmed/19152478]
  78. Lorkowski, G., Gastrointestinal absorption and biological activities of serine and cysteine proteases of animal and plant origin: review on absorption of serine and cysteine proteases. Int J Physiol Pathophysiol Pharmacol, 2012. 4(1): p. 10-27. [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3312459/]
  79. Gaspani, L., et al., In vivo and in vitro Effects of Bromelain on PGE and SP Concentrations in the Inflammatory Exudate in Rats. Pharmacology, 2002. 65(2): p. 83-86. [https://www.ncbi.nlm.nih.gov/pubmed/11937778]
  80. Brien, S., et al., Bromelain as a Treatment for Osteoarthritis: a Review of Clinical Studies. Evid Based Complement Alternat Med., 2004. 1(3): p. 251-257. [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC538506/]
  81. Lotz-Winter, H., On the pharmacology of bromelain: an update with special regard to animal studies on dose-dependent effects. Planta Med, 1990. 56(3): p. 249-53. [https://www.ncbi.nlm.nih.gov/pubmed/2203073]
  82. Taussig, S.J. and S. Batkin, Bromelain, the enzyme complex of pineapple (Ananas comosus) and its clinical application. An update. J Ethnopharmacol, 1988. 22(2): p. 191-203. [https://www.ncbi.nlm.nih.gov/pubmed/3287010]
  83. Pizzorno, J. and M. Murray, Textbook of Natural Medicine. 4th ed. 2012, St. Louis, Missouri: Churchill Livingstone. 1944.
  84. Seligman, B., Oral bromelains as adjuncts in the treatment of acute thrombophlebitis. Angiology, 1969. 20(1): p. 22-6. [https://www.ncbi.nlm.nih.gov/pubmed/4885019]
  85. Pierce, H.E., Jr., Pineapple proteases in the treatment of scleroderma: A case report J Natl Med Assoc, 1964. 56: p. 272-3. [https://www.ncbi.nlm.nih.gov/pubmed/14143037]
  86. Schulz, V., R. Hänsel, and V.E. Tyler, Rational Phytotherapy: A Physicians’ Guide to Herbal Medicine. 3rd ed. 1998, Berlin: Springer-Verlag.
  87. Cohen, A. and J. Goldman, Bromelains therapy in Rheumatoid arthritis. Pa Med J, 1964. 67: p. 27-30. [https://www.ncbi.nlm.nih.gov/pubmed/14174138]
  88. Walker, A.F., et al., Bromelain reduces mild acute knee pain and improves well-being in a dose-dependent fashion in an open study of otherwise healthy adults. Phytomedicine, 2002. 9(8): p. 681-6. [https://www.ncbi.nlm.nih.gov/pubmed/12587686]
  89. Brien, S., et al., Bromelain as an adjunctive treatment for moderate-to-severe osteoarthritis of the knee: a randomized placebo-controlled pilot study. QJM, 2006. 99(12): p. 841-50. [https://www.ncbi.nlm.nih.gov/pubmed/17121765]
  90. Majid, O.W. and B.A. Al-Mashhadani, Perioperative bromelain reduces pain and swelling and improves quality of life measures after mandibular third molar surgery: a randomized, double-blind, placebo-controlled clinical trial. J Oral Maxillofac Surg, 2014. 72(6): p. 1043-8. [https://www.ncbi.nlm.nih.gov/pubmed/24589242]
  91. Arulselvan, P., et al., Role of Antioxidants and Natural Products in Inflammation. Oxid Med Cell Longev, 2016. 2016: p. 5276130. [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5075620/]
  92. Mittal, M., et al., Reactive Oxygen Species in Inflammation and Tissue Injury. Antioxid Redox Signal., 2014. 20(7): p. 1126-1167. [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3929010/]
  93. Kurahashi, T. and J. Fujii, Roles of Antioxidative Enzymes in Wound Healing. Int J Dev Biol, 2015. 3(2): p.57-70. [https://www.mdpi.com/2221-3759/3/2/57]
  94. MacKay, D. and A. Miller, Nutritional Support for Wound Healing. Altern Med Rev, 2003. 8(4): p. 359-77. [https://www.ncbi.nlm.nih.gov/pubmed/14653765]
  95. Lodhi, S., et al., Effects of flavonoids from Martynia annua and Tephrosia purpurea on cutaneous wound healing. Avicenna Journal Of Phytomedicine, 2016. 6(5): p. 578-591. [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5052421/]
  96. Kleemann, R., et al., Anti-inflammatory, anti-proliferative and anti-atherosclerotic effects of quercetin in human in vitro and in vivo models. Atherosclerosis, 2011. 218(1): p. 44-52. [https://www.ncbi.nlm.nih.gov/pubmed/21601209]
  97. Selamoglu, Z., Antioxidant Activity of Quercetin: A Mechanistic Review. Turkish Journal of Agriculture - Food Science and Technology, 2016. 4(12): p. 1134-38. [https://www.researchgate.net/profile/Zeliha_Selamoglu/publication/311773564_Antioxidant_Activity_of_Quercetin_A_Mechanistic_Review/links/585a31bf08ae3852d25674bb/Antioxidant-Activity-of-Quercetin-A-Mechanistic-Review.pdf?origin=publication_detail]
  98. Boesch-Saadatmandi, C., et al., Effect of quercetin and its metabolites isorhamnetin and quercetin-3-glucuronide on inflammatory gene expression: role of miR-155. J Nutr Biochem, 2011. 22(3): p. 293-9. [https://www.ncbi.nlm.nih.gov/pubmed/20579867]
  99. Panchal, S.K., H. Poudyal, and L. Brown, Quercetin Ameliorates Cardiovascular, Hepatic, and Metabolic Changes in Diet-Induced Metabolic Syndrome in Rats. The Journal of Nutrition, 2012. 142(6): p. 1026-1032. [https://www.ncbi.nlm.nih.gov/pubmed/22535755]
  100. Marunaka, Y., et al., Actions of Quercetin, a Polyphenol, on Blood Pressure. Molecules, 2017. 22(2):209. [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155806/]
  101. Weng, Z., et al., Quercetin is more effective than cromolyn in blocking human mast cell cytokine release and inhibits contact dermatitis and photosensitivity in humans. PLoS One, 2012. 7(3): p. e33805. [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3314669/]
  102. Mills, S. and K. Bone, Principles and Practice of Phytotherapy: Modern Herbal Medicine. 2000, Edinburgh: Churchill Livingstone.
  103. Kelly, G.S., Quercetin. Monograph. Altern Med Rev, 2011. 16(2): p. 172-94. [http://www.altmedrev.com/archive/publications/16/2/172.pdf]
  104. Chow, J.M., et al., Quercetin, but not rutin and quercitrin, prevention of H2O2-induced apoptosis via anti-oxidant activity and heme oxygenase 1 gene expression in macrophages. Biochem Pharmacol, 2005. 69(12): p. 1839-51. [https://www.ncbi.nlm.nih.gov/pubmed/15876423]
  105. Tarayre, J.P. and H. Lauressergues, Advantages of a combination of proteolytic enzymes, flavonoids and ascorbic acid in comparison with non-steroid anti-inflammatory agents. Arzneimittel-Forschung, 1977. 27(6): p. 1144-1149. [https://www.ncbi.nlm.nih.gov/pubmed/578429]
  106. Middleton, E., Jr., C. Kandaswami, and T.C. Theoharides, The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer. Pharmacol Rev, 2000. 52(4): p. 673-751. [https://www.ncbi.nlm.nih.gov/pubmed/11121513]
  107. Carr, A.C. and M.C. Vissers, Synthetic or food-derived vitamin C--are they equally bioavailable? Nutrients, 2013. 5(11): p. 4284-304. [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3847730/]
  108. Shi, Y. and G. Williamson, Quercetin lowers plasma uric acid in pre-hyperuricaemic males: a randomised, double-blinded, placebo-controlled, cross-over trial. Br J Nutr, 2016. 115(5): p. 800-6. [https://www.ncbi.nlm.nih.gov/pubmed/26785820]
  109. Egert, S., et al., Quercetin reduces systolic blood pressure and plasma oxidised low-density lipoprotein concentrations in overweight subjects with a high-cardiovascular disease risk phenotype: a double-blinded, placebo-controlled cross-over study. Br J Nutr, 2009. 102(7): p. 1065-74. [https://www.ncbi.nlm.nih.gov/pubmed/19402938]
  110. Edwards, R.L., et al., Quercetin reduces blood pressure in hypertensive subjects. J Nutr, 2007. 137(11): p. 2405-11. [https://www.ncbi.nlm.nih.gov/pubmed/17951477]
  111. Zahedi, M., et al., Does Quercetin Improve Cardiovascular Risk factors and Inflammatory Biomarkers in Women with Type 2 Diabetes: A Double-blind Randomized Controlled Clinical Trial. International Journal of Preventive Medicine, 2013. 4(7): p. 777-785. [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3775217/]
  112. Javadi, F., et al., The Effect of Quercetin on Inflammatory Factors and Clinical Symptoms in Women with Rheumatoid Arthritis: A Double-Blind, Randomized Controlled Trial. J Am Coll Nutr, 2017. 36(1): p. 9-15. [https://www.ncbi.nlm.nih.gov/pubmed/27710596]
  113. Shoskes, D.A., et al., Quercetin in men with category III chronic prostatitis: a preliminary prospective, double-blind, placebo-controlled trial. Urology, 1999. 54(6): p. 960-3. [https://www.ncbi.nlm.nih.gov/pubmed/10604689]
  114. Boots, A.W., et al., Quercetin reduces markers of oxidative stress and inflammation in sarcoidosis. Clin Nutr, 2011. 30(4): p. 506-12. [https://www.ncbi.nlm.nih.gov/pubmed/21324570]
  115. DePhillipo, N.N., et al., Efficacy of Vitamin C Supplementation on Collagen Synthesis and Oxidative Stress After Musculoskeletal Injuries: A Systematic Review. Orthop J Sports Med, 2018. 6(10): p. 2325967118804544. [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204628/]
  116. Aghajanian, P., et al., The Roles and Mechanisms of Actions of Vitamin C in Bone: New Developments. J Bone Miner Res, 2015. 30(11): p. 1945-1955. [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4833003/]
  117. Pullar, J.M., A.C. Carr, and M.C.M. Vissers, The Roles of Vitamin C in Skin Health. Nutrients, 2017. 9(8): p. 866. [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5579659/]
  118. Chambial, S., et al., Vitamin C in disease prevention and cure: an overview. Indian J Clin Biochem, 2013. 28(4): p. 314-328. [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3783921/]
  119. Kjaer, M., et al., From mechanical loading to collagen synthesis, structural changes and function in human tendon. Scand J Med Sci Sports, 2009. 19(4): p. 500-10. [https://www.ncbi.nlm.nih.gov/pubmed/19706001]
  120. Padayatty, S.J. and M. Levine, Vitamin C physiology: the known and the unknown and Goldilocks. Oral diseases, 2016. 22(6): p. 463-493. [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4959991/]
  121. Bikker, A., et al., Ascorbic acid deficiency impairs wound healing in surgical patients: Four case reports. Int J Surg Open, 2016. 2: p. 15-18. [https://www.researchgate.net/profile/Jos_Wielders/publication/296693849_Ascorbic_acid_deficiency_impairs_wound_healing_in_surgical_patients_Four_case_reports/links/59c23c3f458515af30607225/Ascorbic-acid-deficiency-impairs-wound-healing-in-surgical-patients-Four-case-reports.pdf?origin=publication_detail]
  122. Padayatty, S., et al., Vitamin C as an Antioxidant: Evaluation of Its Role in Disease Prevention. J Am Coll Nutr, 22(1): p. 18-35. [https://www.ncbi.nlm.nih.gov/pubmed/12569111]
  123. Carr, A.C. and C. McCall, The role of vitamin C in the treatment of pain: new insights. Journal of Translational Medicine, 2017. 15: p. 77. [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5391567/]
  124. Khan, R.A., N. Mallick, and Z. Feroz, Anti-inflammatory effects of Citrus sinensis L., Citrus paradisi L. and their combinations. Pak J Pharm Sci, 2016. 29(3): p. 843-52. [https://www.ncbi.nlm.nih.gov/pubmed/27166529]
  125. Sangeetha, K.S.S., et al., Flavonoids: Therapeutic potential of natural pharmacological agents. Int J Pharm Sci Res, 2016. 7(10): p. 3924-30. [https://www.researchgate.net/profile/Uma_S2/publication/313315308_FLAVONOIDS_THERAPEUTIC_POTENTIAL_OF_NATURAL_PHARMACOLOGICAL_AGENTS/links/5895c0e84585158bf6f0644a/FLAVONOIDS-THERAPEUTIC-POTENTIAL-OF-NATURAL-PHARMACOLOGICAL-AGENTS.pdf?origin=publication_detail]
  126. Akhtar, N.M., et al., Oral enzyme combination versus diclofenac in the treatment of osteoarthritis of the knee--a double-blind prospective randomized study. Clin Rheumatol, 2004. 23(5): p. 410-5. [https://www.ncbi.nlm.nih.gov/pubmed/15278753]
  127. Hall, S.T. Thesis: Efficacy of oral enzyme combination vs. diclofenac in the management of large joint osteoarthritis: A systematic review., Pacific Univeristy, 2012. [https://pdfs.semanticscholar.org/0833/af8d9e6796458304808ad7e0f445d57f5aac.pdf?_ga=2.113401103.929157131.1579650653-1392211995.1576463823]
  128. Singer, F., C. Singer, and H. Oberleitner, Phlogenzym® versus diclofenac in the treatment of activated osteoarthritis of the knee. A double-blind prospective randomized study. Vol. 17. 2001. 135-141. [https://www.researchgate.net/publication/288688120_PhlogenzymR_versus_diclofenac_in_the_treatment_of_activated_osteoarthritis_of_the_knee_A_double-blind_prospective_randomized_study]
  129. Klein, G., et al., Efficacy and tolerance of an oral enzyme combination in painful osteoarthritis of the hip. A double-blind, randomised study comparing oral enzymes with non-steroidal anti-inflammatory drugs. Clin Exp Rheumatol, 2006. 24(1): p. 25-30. [https://www.ncbi.nlm.nih.gov/pubmed/16539815]
  130. Duchesne, E., S.S. Dufresne, and N.A. Dumont, Impact of Inflammation and Anti-inflammatory Modalities on Skeletal Muscle Healing: From Fundamental Research to the Clinic. Physical Therapy, 2017. 97(8): p. 807-817. [https://www.ncbi.nlm.nih.gov/pubmed/28789470]
  131. Harty, P.S., et al., Nutritional and Supplementation Strategies to Prevent and Attenuate Exercise-Induced Muscle Damage: a Brief Review. Sports Med Open, 2019. 5(1): p. 1. [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323061/]
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