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References - Eagle Serene Mind Tech Sheet

1. Health Canada [Internet]. Ottowa (ON): Health Canada; 2025. Ashwagandha – Withania somnifera; 2025 Feb [cited 2025 Jul 2]. Available from: https://webprod.hc-sc.gc.ca/nhpid-bdipsn/atReq?atid=ashwagandha2&lang=eng

2. Pole S. Ayurvedic medicine: the principles of traditional practice. Philadelphia: Churchill Livingstone; 2006.

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5. Mehta AK, Binkley P, Gandhi SS, Ticku MK. Pharmacological effects of Withania somnifera root extract on GABAA receptor complex. Indian J Med Res. 1991 Aug;94:312-315.

6. Della Porta M, Maier JA, Cazzola R. Effects of Withania somnifera on cortisol levels in stressed human subjects: a systematic review. Nutrients. 2023 Dec;15(24):5015. DOI: 10.3390/nu15245015

7. Braun L, Cohen M. Herbs & natural supplements, volume 2: an evidence-based guide. 4th ed. Sydney: Churchill Livingstone; 2015.

8. Health Canada [Internet]. Ottowa (ON): Health Canada; 2024. Passionflower – Passiflora incarnata; 2024 Nov [cited 2025 Jul 2]. Available from: https://webprod.hc-sc.gc.ca/nhpid-bdipsn/atReq?atid=passionflower.passiflore&lang=eng

9. Krenn L. [Passion Flower (Passiflora incarnata L.)--a reliable herbal sedative]. Wien Med Wochenschr. 2002;152(15-16):404-406. DOI: 10.1046/j.1563-258x.2002.02062.x

10. Appel K, Rose T, Fiebich B, Kammler T, Hoffmann C, Weiss G. Modulation of the γ-aminobutyric acid (GABA) system by Passiflora incarnata L. Phytother Res. 2011 Jun;25(6):838-843. DOI: 10.1002/ptr.3352

11. Health Canada [Internet]. Ottowa (ON): Health Canada; 2024. Lemon balm – Melissa officinalis; 2024 Apr [cited 2025 Jul 2]. Available from: https://webprod.hc-sc.gc.ca/nhpid-bdipsn/atReq?atid=lemon.balm&lang=eng

12. Awad R, Muhammad A, Durst T, Trudeau VL, Arnason JT. Bioassay-guided fractionation of lemon balm (Melissa officinalis L.) using an in vitro measure of GABA transaminase activity. Phytother Res. 2009 Aug;23(8):1075-1081. DOI: 10.1002/ptr.2712

13. Chandrasekhar K, Kapoor J, Anishetty S. A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults. Indian J Psychol Med. 2012 Jul;34(3):255-262. DOI: 10.4103/0253-7176.106022

14. Siwek M, Woroń J, Wrzosek A, Gupało J, Chrobak AA. Harder, better, faster, stronger? Retrospective chart review of adverse events of interactions between adaptogens and antidepressant drugs. Front Pharmacol. 2023 Sep:14:1271776. DOI: 10.3389/fphar.2023.1271776

15. Majeed M, Nagabhushanam K, Murali A, Vishwanathan DT, Mamidala RV, Mundkur L. A standardized Withania somniferra (Linn.) root extract with piperine alleviates the symptoms of anxiety and depression by increasing serotonin levels: a double-blind, randomized, placebo-controlled study. J Integr Complement Med. 2024 May;30(5):459-468. DOI: 10.1089/jicm.2023.0279

16. Tandon N, Yadav SS. Safety and clinical effectiveness of Withania Somnifera (Linn.) Dunal root in human ailments. J Ethnopharmacol. 2020 Jun;255:112768. DOI: 10.1016/j.jep.2020.112768

17. Gannon JM, Brar J, Rai A, Chengappa KNR. Effects of a standardized extract of Withania somnifera (Ashwagandha) on depression and anxiety symptoms in persons with schizophrenia participating in a randomized, placebo-controlled clinical trial. Ann Clin Psychiatry. 2019 May;31(2):123-129.

18. Hayashi M, Hamada H, Azuma SI, Hayashi K. Painless thyroiditis by Withania somnifera (ashwagandha). Cureus. 2024 Mar;16(3):e55352. DOI: 10.7759/cureus.55352

19. Kamal HI, Patel K, Brdak A, Heffernan J, Ahmad N. Ashwagandha as a unique cause of thyrotoxicosis presenting with supraventricular tachycardia. Cureus. 2022 Mar;14(3):e23494. DOI: 10.7759/cureus.23494

20. Curry KM, McNeil LE, Flores A, Fuks J. Thyrotoxicosis with ashwagandha: a case report. SSRN. 2019 Dec. DOI: 10.2139/ssrn.3506409

21. Van Der Hooft CS, Hoekstra A, Winter A, De Smet PAG, Stricker BHC. [Thyrotoxicosis following the use of ashwagandha]. Ned Tijdschr Geneeskd. 2005 Nov;149(47):2637-2638.

22. Fatima K, Malik J, Muskan F, Raza G, Waseem A, Shahid H, et al. Safety and efficacy of Withania somnifera for anxiety and insomnia: systematic review and meta-analysis. Hum Psychopharmacol. 2024 Nov;39(6):e2911. DOI: 10.1002/hup.2911

23. Akhondzadeh S, Naghavi HR, Vazirian M, Shayeganpour A, Rashidi H, Khani M. Passionflower in the treatment of generalized anxiety: a pilot double-blind randomized controlled trial with oxazepam. J Clin Pharm Ther. 2001 Oct;26(5):363-367. DOI: 10.1046/j.1365-2710.2001.00367.x

24. Kennedy DO, Little W, Scholey AB. Attenuation of laboratory-induced stress in humans after acute administration of Melissa officinalis (lemon balm). Psychosom Med. 2004 Jul-Aug;66(4):607-613. DOI: 10.1097/01.psy.0000132877.72833.71

25. Harit MK, Mundhe N, Tamoli S, Pawar V, Bhapkar V, Kolhe G, et al. Randomized, double-blind, placebo-controlled, clinical study of Passiflora incarnata in participants with stress and sleep problems. Cureus. 2024 Mar;16(3):e56530. DOI: 10.7759/cureus.56530

26. Cases J, Ibarra A, Feuillère N, Roller M, Sukkar SG. Pilot trial of Melissa officinalis L. leaf extract in the treatment of volunteers suffering from mild-to-moderate anxiety disorders and sleep disturbances. Med J Nutrition Metab. 2011 Dec;4(3):211-218. DOI: 10.1007/s12349-010-0045-4

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