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References - Curcuminoid Phospholipid Complex

  1. Anand P, Kunnumakkara AB, Newman RA, Aggarwal BB. Bioavailability of curcumin: problems and promises. Molecular pharmaceutics. 2007 Dec 3;4(6):807-18.
  2. Marczylo TH, Verschoyle RD, Cooke DN, Morazzoni P, Steward WP, Gescher AJ. Comparison of systemic availability of curcumin with that of curcumin formulated with phosphatidylcholine. Cancer chemotherapy and pharmacology. 2007 Jul;60(2):171-7.
  3. Wichtl M. Herbal drugs and phytopharmaceuticals: a handbook for practice on a scientific basis. Medpharm GmbH Scientific Publishers; 2004.
  4. Wichitnithad W, Jongaroonngamsang N, Pummangura S, Rojsitthisak P. A simple isocratic HPLC method for the simultaneous determination of curcuminoids in commercial turmeric extracts. Phytochemical Analysis. 2009 Jul;20(4):314-9.
  5. Zhou H, S Beevers C, Huang S. The targets of curcumin. Current drug targets. 2011 Mar 1;12(3):332-47.
  6. Zhou H, S Beevers C, Huang S. The targets of curcumin. Current drug targets. 2011 Mar 1;12(3):332-47.
  7. Esatbeyoglu T, Huebbe P, Ernst IM, Chin D, Wagner AE, Rimbach G. Curcumin—from molecule to biological function. Angewandte Chemie International Edition. 2012 May 29;51(22):5308-32.
  8. Kusuhara H, Furuie H, Inano A, Sunagawa A, Yamada S, Wu C, et al. Pharmacokinetic interaction study of sulphasalazine in healthy subjects and the impact of curcumin as an in vivo inhibitor of BCRP. Br J Clin Pharmacol. 2012 Jul;166(6):1793-803.
  9. Rasyid A, Rahman AR, Jaalam K, Lelo A. Effect of different curcumin dosages on human gall bladder. Asia Pac J Clin Nutr 2002;11:314-8.
  10. Cuomo J, Appendino G, Dern AS, Schneider E, McKinnon TP, Brown MJ, Togni S, Dixon BM. Comparative absorption of a standardized curcuminoid mixture and its lecithin formulation. Journal of natural products. 2011 Apr 25;74(4):664-9.
  11. Purpura M, Lowery RP, Wilson JM et al. Eur J Nutr 2018; 57(3): 929-938
  12. Asher GN, Xie Y, Moaddel R, Sanghvi M, Dossou KS, Kashuba AD, Sandler RS, Hawke RL. Randomized pharmacokinetic crossover study comparing 2 curcumin preparations in plasma and rectal tissue of healthy human volunteers. The Journal of Clinical Pharmacology. 2017 Feb;57(2):185-93.
  13. Purpura M, Lowery RP, Wilson JM et al. Eur J Nutr 2018; 57(3): 929-938
  14. Purpura M, Lowery RP, Wilson JM et al. Eur J Nutr 2018; 57(3): 929-938
  15. Asher GN, Xie Y, Moaddel R, Sanghvi M, Dossou KS, Kashuba AD, Sandler RS, Hawke RL. Randomized pharmacokinetic crossover study comparing 2 curcumin preparations in plasma and rectal tissue of healthy human volunteers. The Journal of Clinical Pharmacology. 2017 Feb;57(2):185-93.
  16. Asher GN, Xie Y, Moaddel R, Sanghvi M, Dossou KS, Kashuba AD, Sandler RS, Hawke RL. Randomized pharmacokinetic crossover study comparing 2 curcumin preparations in plasma and rectal tissue of healthy human volunteers. The Journal of Clinical Pharmacology. 2017 Feb;57(2):185-93.
  17. Belcaro G, Cesarone MR, Dugall M, Pellegrini L, Ledda A, Grossi MG, Togni S, Appendino G. Efficacy and safety of Meriva®, a curcumin-phosphatidylcholine complex, during extended administration in osteoarthritis patients. Altern Med Rev. 2010 Dec 1;15(4):337-44.
  18. Belcaro G, Cesarone MR, Dugall M, Pellegrini L, Ledda A, Grossi MG, Togni S, Appendino G. Product-evaluation registry of Meriva®, a curcumin-phosphatidylcholine complex, for the complementary management of osteoarthritis. Panminerva Med. 2010 Jun 1;52(2 Suppl 1):55-62.
  19. Belcaro G, Cesarone MR, Dugall M, Pellegrini L, Ledda A, Grossi MG, Togni S, Appendino G. Efficacy and safety of Meriva®, a curcumin-phosphatidylcholine complex, during extended administration in osteoarthritis patients. Altern Med Rev. 2010 Dec 1;15(4):337-44.
  20. Belcaro G, Dugall M, Luzzi R, Ledda A, Pellegrini L, Cesarone MR, Hosoi M, Errichi M. Meriva (R)+ glucosamine versus condroitin+ glucosamine in patients with knee osteoarthritis: An observational study. Eur Rev Med Pharmacol Sci. 2014 Jan 1;18(24):3959-63.
  21. Appendino G, Belcaro G, Cornelli U, Luzzi R, Togni S, Dugall M, Cesarone MR, Feragalli B, Ippolito E, Errichi BM, Pellegrini L. Potential role of curcumin phytosome (Meriva) in controlling the evolution of diabetic microangiopathy. A pilot study. Panminerva Med. 2011 Sep 1;53(3 Suppl 1):43-9.
  22. Steigerwalt R, Nebbioso M, Appendino G et al. Panminerva Med 2012; 54(1 Suppl 4): 11-16
  23. Mazzolani F, Togni S, Giacomelli L, Eggenhoffner R, Franceschi F. Oral administration of a curcumin-phospholipid formulation (Meriva®) for treatment of chronic diabetic macular edema: A pilot study. Eur Rev Med Pharmacol Sci. 2018 Jun 1;22(11):3617-25.
  24. Allegri P, Mastromarino A, Neri P. Management of chronic anterior uveitis relapses: efficacy of oral phospholipidic curcumin treatment. Long-term follow-up. Clinical Ophthalmology (Auckland, NZ). 2010;4:1201.
  25. Tuyaerts S, Rombauts K, Everaert T, Van Nuffel AM, Amant F. A phase 2 study to assess the immunomodulatory capacity of a lecithin-based delivery system of curcumin in endometrial cancer. Frontiers in nutrition. 2019 Jan 11;5:138.
  26. Panahi Y, Saadat A, Beiraghdar F, Sahebkar A. Adjuvant therapy with bioavailability‐boosted curcuminoids suppresses systemic inflammation and improves quality of life in patients with solid tumors: a randomized double‐blind placebo‐controlled trial. Phytotherapy Research. 2014 Oct;28(10):1461-7.
  27. Serpe R, Madedda C, Panzone F et al. J Cachexia Sarcopenia Muscle 2011; 2(4): 257
  28. Pastorelli D, Fabricio AS, Giovanis P, D'Ippolito S, Fiduccia P, Soldà C, Buda A, Sperti C, Bardini R, Da Dalt G, Rainato G. Phytosome complex of curcumin as complementary therapy of advanced pancreatic cancer improves safety and efficacy of gemcitabine: Results of a prospective phase II trial. Pharmacological research. 2018 Jun 1;132:72-9.
  29. Belcaro G, Hosoi M, Pellegrini L, Appendino G, Ippolito E, Ricci A, Ledda A, Dugall M, Cesarone MR, Maione C, Ciammaichella G. A controlled study of a lecithinized delivery system of curcumin (Meriva®) to alleviate the adverse effects of cancer treatment. Phytotherapy Research. 2014 Mar;28(3):444-50.
  30. Miller AH. Phase II Study of Curcumin vs Placebo for Chemotherapy-Treated Breast Cancer Patients Undergoing Radiotherapy. Available online: https:// clinicaltrials.gov/ct2/show/NCT01740323. Accessed September 2019.
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  32. Sharma RA, Euden SA, Platton SL, Cooke DN, Shafayat A, Hewitt HR, Marczylo TH, Morgan B, Hemingway D, Plummer SM, Pirmohamed M. Phase I clinical trial of oral curcumin: biomarkers of systemic activity and compliance. Clinical Cancer Research. 2004 Oct 15;10(20):6847-54.
  33. He ZY, Shi CB, Wen H, Li FL, Wang BL, Wang J. Upregulation of p53 expression in patients with colorectal cancer by administration of curcumin. Cancer investigation. 2011 Feb 15;29(3):208-13.
  34. Howells LM, Iwuji CO, Irving GR, Barber S, Walter H, Sidat Z, Griffin-Teall N, Singh R, Foreman N, Patel SR, Morgan B. Curcumin combined with FOLFOX chemotherapy is safe and tolerable in patients with metastatic colorectal cancer in a randomized phase IIa trial. The Journal of nutrition. 2019 Jul 1;149(7):1133-9.
  35. Gunther JR, Chadha AS, Yang P, Munsell MF, Das P, Delclos ME, Foo WC, Kaur H, Clemons M, Mathew GG, Chang GJ. (S021) A Phase 2 Randomized Double Blinded Study Evaluating the Efficacy of Curcumin With Pre-Operative Chemoradiation for Rectal Cancer. International Journal of Radiation Oncology, Biology, Physics. 2017 Jun 1;98(2):E7.
  36. Bayet-Robert M, Kwiatowski F, Leheurteur M, Gachon F, Planchat E, Abrial C, Mouret-Reynier MA, Durando X, Barthomeuf C, Chollet P. Phase I dose escalation trial of docetaxel plus curcumin in patients with advanced and metastatic breast cancer. Cancer biology & therapy. 2010 Jan 1;9(1):8-14.
  37. Ryan JL, Heckler CE, Ling M, Katz A, Williams JP, Pentland AP, Morrow GR. Curcumin for radiation dermatitis: a randomized, double-blind, placebo-controlled clinical trial of thirty breast cancer patients. Radiation research. 2013 Jul;180(1):34-43.
  38. Ryan Wolf J, Heckler CE, Guido JJ, Peoples AR, Gewandter JS, Ling M, Vinciguerra VP, Anderson T, Evans L, Wade J, Pentland AP. Oral curcumin for radiation dermatitis: A URCC NCORP study of 686 breast cancer patients. Supportive Care in Cancer. 2018 May;26(5):1543-52.
  39. Dhillon N, Aggarwal BB, Newman RA, Wolff RA, Kunnumakkara AB, Abbruzzese JL, Ng CS, Badmaev V, Kurzrock R. Phase II trial of curcumin in patients with advanced pancreatic cancer. Clinical cancer research. 2008 Jul 15;14(14):4491-9.
  40. Parsons HA, Baracos VE, Hong DS et al. Oncotarget 2016; 7(15): 20293-202304
  41. Epelbaum R, Schaffer M, Vizel B, Badmaev V, Bar-Sela G. Curcumin and gemcitabine in patients with advanced pancreatic cancer. Nutrition and cancer. 2010 Nov 5;62(8):1137-41.
  42. Shacham-Shmueli E, Geva R, Galazan L et al. Ann Oncol 2009; 20(Supp7): 106
  43. Kanai M, Yoshimura K, Asada M, Imaizumi A, Suzuki C, Matsumoto S, Nishimura T, Mori Y, Masui T, Kawaguchi Y, Yanagihara K. A phase I/II study of gemcitabine-based chemotherapy plus curcumin for patients with gemcitabine-resistant pancreatic cancer. Cancer chemotherapy and pharmacology. 2011 Jul;68(1):157-64.
  44. Bansal N. Chauhan AK Kaur P, et al. A prospective study to evaluate the role of curcumin in treatment of locally advanced carcinoma of cervix. Int J Radiol Radiat Ther. 2018;5(4):220-5.
  45. Choi YH, Han DH, Kim SW, Kim MJ, Sung HH, Jeon HG, Jeong BC, Seo SI, Jeon SS, Lee HM, Choi HY. A randomized, double‐blind, placebo‐controlled trial to evaluate the role of curcumin in prostate cancer patients with intermittent androgen deprivation. The Prostate. 2019 May;79(6):614-21.
  46. Mahammedi H, Planchat E, Pouget M, Durando X, Curé H, Guy L, Van-Praagh I, Savareux L, Atger M, Bayet-Robert M, Gadea E. The new combination docetaxel, prednisone and curcumin in patients with castration-resistant prostate cancer: a pilot phase II study. Oncology. 2016;90(2):69-78.
  47. Santosa D, Suharti C, Riwanto I et al. HemaSphere 2019; 3(Suppl 1): 975
  48. Thota RN, Acharya SH, Garg ML. Curcumin and/or omega-3 polyunsaturated fatty acids supplementation reduces insulin resistance and blood lipids in individuals with high risk of type 2 diabetes: a randomised controlled trial. Lipids in health and disease. 2019 Dec;18(1):1-1.
  49. Drobnic F, Riera J, Appendino G, Togni S, Franceschi F, Valle X, Pons A, Tur J. Reduction of delayed onset muscle soreness by a novel curcumin delivery system (Meriva®): a randomised, placebo-controlled trial. Journal of the International Society of Sports Nutrition. 2014 Jun 18;11(1):31.
  50. Sciberras JN, Galloway SD, Fenech A, Grech G, Farrugia C, Duca D, Mifsud J. The effect of turmeric (Curcumin) supplementation on cytokine and inflammatory marker responses following 2 hours of endurance cycling. Journal of the International Society of Sports Nutrition. 2015 Jan 21;12(1):5.
  51. Szymanski MC, Gillum TL, Gould LM, Morin DS, Kuennen MR. Short-term dietary curcumin supplementation reduces gastrointestinal barrier damage and physiological strain responses during exertional heat stress. Journal of Applied Physiology. 2018 Feb 1;124(2):330-40.
  52. Nicol LM, Rowlands DS, Fazakerly R, Kellett J. Curcumin supplementation likely attenuates delayed onset muscle soreness (DOMS). European journal of applied physiology. 2015 Aug;115(8):1769-77.
  53. Franceschi F, Feregalli B, Togni S, Cornelli U, Giacomelli L, Eggenhoffner R, Belcaro G. A novel phospholipid delivery system of curcumin (Meriva®) preserves muscular mass in healthy aging subjects. Eur. Rev. Med. Pharmacol. Sci. 2016 Jan 1;20(4):762-6.
  54. Di Pierro F, Settembre R. Safety and efficacy of an add-on therapy with curcumin phytosome and piperine and/or lipoic acid in subjects with a diagnosis of peripheral neuropathy treated with dexibuprofen. Journal of Pain Research. 2013;6:497.
  55. Panahi Y, Kianpour P, Mohtashami R, Jafari R, Simental-Mendía LE, Sahebkar A. Efficacy and safety of phytosomal curcumin in non-alcoholic fatty liver disease: a randomized controlled trial. Drug research. 2017 Apr;67(04):244-51.
  56. Ledda A, Belcaro G, Dugall M, Luzzi R, Scoccianti M, Togni S, Appendino G, Ciammaichella G. Meriva®, a lecithinized curcumin delivery system, in the control of benign prostatic hyperplasia: a pilot, product evaluation registry study. Panminerva Medica. 2012 Dec 1;54(4):17.
  57. Antiga E, Bonciolini V, Volpi W, Del Bianco E, Caproni M. Oral curcumin (Meriva) is effective as an adjuvant treatment and is able to reduce IL-22 serum levels in patients with psoriasis vulgaris. BioMed research international. 2015 Oct;2015.
  58. Appendino G, Belcaro G, Cornelli U, Luzzi R, Togni S, Dugall M, Cesarone MR, Feragalli B, Ippolito E, Errichi BM, Pellegrini L. Potential role of curcumin phytosome (Meriva) in controlling the evolution of diabetic microangiopathy. A pilot study. Panminerva Med. 2011 Sep 1;53(3 Suppl 1):43-9.
  59. Riva A, Togni S, Giacomelli L, Franceschi F, Eggenhoffner R, Feragalli B, Belcaro G, Cacchio M, Shu H, Dugall M. Effects of a curcumin-based supplementation in asymptomatic subjects with low bone density: a preliminary 24-week supplement study. Eur Rev Med Pharmacol Sci. 2017 Apr 1;21(7):1684-9.
  60. van Campen CL, Riepma K, Visser FC. The effect of curcumin on patients with chronic fatigue syndrome/myalgic encephalomyelitis: An open label study. International Journal of Clinical Medicine. 2018 May 9;9(05):356.
  61. Shah BH, Nawaz Z, Pertani SA, Roomi A, Mahmood H, Saeed SA, et al. Inhibitory effect of curcumin, a food spice from turmeric, on platelet-activating factor-and arachidonic acid-mediated platelet aggregation through inhibition of thromboxane formation and Ca2+ signaling. Biochem Pharmacol. 1999 Oct 1;58(7):1167-72.
  62. Appiah-Opong R, Commandeur JN, Vugt-Lussenburg B, Vermeulen NP. Inhibition of human recombinant cytochrome P450s by curcumin and curcumin decomposition products. Toxicology 6-3-2007;235(1-2):83-91
  63. Nayeri A, Wu S, Adams E, et al. Acute Calcineurin Inhibitor Nephrotoxicity Secondary to Turmeric Intake: A Case Report. Transplant Proc. 2017;49(1):198-200
  64. UPCM Children’s Hospital of Pittsburgh. Cyclosporine (Sandimmune®, Neoral®) Uses and Side Effects [Internet]. USA [cited 2022 Apr 11]. Available from: https://www.chp.edu/our-services/transplant/liver/education/medications/cyclosporine-sandimmune-neoral
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