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References - Coenzyme Q10 for Cardiovascular Health and Antioxidant Protection

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  30. Littarru, G.P. and L. Tiano, Bioenergetic and Antioxidant Properties of Coenzyme Q10: Recent Developments. Molecular Biotechnology, 2007. 37(1): p. 31-37.
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  35. Qu, H., et al., Effects of Coenzyme Q10 on Statin‐Induced Myopathy: An Updated Meta‐Analysis of Randomized Controlled Trials. J Am Heart Assoc, 2018. 7(19): p. e009835.
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  39. Shults, C.W., et al., Effects of coenzyme Q10 in early Parkinson disease: evidence of slowing of the functional decline. Arch Neurol, 2002. 59(10): p. 1541-50.
  40. Barcelos, I.P. and R.H. Haas, CoQ10 and Aging. Biology (Basel), 2019. 8(2).
  41. Wada, H. and H. Goto, Redox status of coenzyme Q10 is associated with chronological age. Journal of the American Geriatrics Society, 2007. 55(7).
  42. Bhagavan, H.N. and R.K. Chopra, Coenzyme Q10: absorption, tissue uptake, metabolism and pharmacokinetics. Free Radic Res, 2006. 40(5): p. 445-53.
  43. Bhagavan, H.N. and R.K. Chopra, Plasma coenzyme Q10 response to oral ingestion of coenzyme Q10 formulations. Mitochondrion, 2007. 7 Suppl: p. S78-88.
  44. Langsjoen, P.H. and A.M. Langsjoen, Comparison study of plasma coenzyme Q10 levels in healthy subjects supplemented with ubiquinol versus ubiquinone. Clinical Pharmacology in Drug Development, 2014. 3(1): p. 13-17.
  45. Miles, M., et al., Bioequivalence of coenzyme Q10 from over the counter supplements. Nutrition Research, 2002. 22: p. 919-929.
  46. Lopez-Lluch, G., et al., Bioavailability of coenzyme Q10 supplements depends on carrier lipids and solubilization. Nutrition, 2019. 57: p. 133-140.
  47. Evans, M., et al., A randomized, double-blind trial on the bioavailability of two CoQ10 formulations. Journal of Functional Foods, 2009. 1(1): p. 65-73.
  48. Shults, C.W., et al., Pilot trial of high dosages of coenzyme Q10 in patients with Parkinson's disease. Exp Neurol, 2004. 188(2): p. 491-4.
  49. Hosoe, K., et al., Study on safety and bioavailability of ubiquinol (Kaneka QH) after single and 4-week multiple oral administration to healthy volunteers. Regul Toxicol Pharmacol, 2007. 47(1): p. 19-28.
  50. Beal, M., et al., A Randomized Clinical Trial of High-Dosage Coenzyme Q10 in Early Parkinson Disease. JAMA Neurology, 2014. 71: p. 543-552.
  51. Hathcock, J.N. and A. Shao, Risk assessment for coenzyme Q10 (Ubiquinone). Regul Toxicol Pharmacol, 2006. 45(3): p. 282-8.
  52. Díaz-Casado, M.E., et al., The Paradox of Coenzyme Q(10) in Aging. Nutrients, 2019. 11(9): p. 2221.
  53. Ikematsu, H., et al., Safety assessment of coenzyme Q10 (Kaneka Q10) in healthy subjects: a double-blind, randomized, placebo-controlled trial. Regulatory Toxicology and Pharmacology, 2006. 44(3): p. 212-8.
  54. Hidaka, T., et al., Safety assessment of coenzyme Q10 (CoQ10). BioFactors (Oxford, England), 2008. 32: p. 199-208.
  55. Heck, A.M., B.A. DeWitt, and A.L. Lukes, Potential interactions between alternative therapies and warfarin. Am J Health Syst Pharm, 2000. 57(13): p. 1221-7; quiz 1228-30.
  56. Engelsen, J., J.D. Nielsen, and K.F. Hansen, [Effect of Coenzyme Q10 and Ginkgo biloba on warfarin dosage in patients on long-term warfarin treatment. A randomized, double-blind, placebo-controlled cross-over trial]. Ugeskr Laeger, 2003. 165(18): p. 1868-71.
  57. Shalansky, S., et al., Risk of Warfarin-Related Bleeding Events and Supratherapeutic International Normalized Ratios Associated with Complementary and Alternative Medicine: A Longitudinal Analysis. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 2007. 27(9): p. 1237-1247.
  58. Moludi, J., et al., Coenzyme Q10 effect in prevention of atrial fibrillation after Coronary Artery Bypass Graft: double-blind randomized clinical trial. Tehran University Medical Journal, 2015. 73(2): p. 79-85.
  59. Belardinelli, R., et al., Coenzyme Q10 and exercise training in chronic heart failure. Eur Heart J, 2006. 27(22): p. 2675-81.
  60. Munkholm, H., H.H. Hansen, and K. Rasmussen, Coenzyme Q10 treatment in serious heart failure. Biofactors, 1999. 9(2-4): p. 285-9.
  61. Hosseini, V., Comparison of coenzyme Q10 versus placebo in chronic heart failure. Research Journal of Biological Sciences, 2008. 3(6): p. 546-549.
  62. Mortensen, A., F. Rosenfeldt, and K. Filipiak, Effect of coenzyme Q10 in Europeans with chronic heart failure: A sub-group analysis of the Q-SYMBIO randomized double-blind trial. Cardiology Journal, 2013. 26.
  63. Singh, R.B., et al., Effect of coenzyme Q10 on risk of atherosclerosis in patients with recent myocardial infarction. Mol Cell Biochem, 2003. 246(1-2): p. 75-82.
  64. Cooke, M., et al., Effects of acute and 14-day coenzyme Q10 supplementation on exercise performance in both trained and untrained individuals. J Int Soc Sports Nutr, 2008. 5: p. 8.
  65. Gharahdaghi, N., et al., The Effects of Daily Coenzyme Q10 Supplementation on VO2max, vVO2max and Intermittent Exercise Performance in Soccer Players. Life Science Journal, 2013. 10(8s): p. 22-28.
  66. Mizuno, K., et al., Antifatigue effects of coenzyme Q10 during physical fatigue. Nutrition (Burbank, Los Angeles County, Calif.), 2008. 24: p. 293-9.
  67. Cordero, M.D., et al., Can coenzyme q10 improve clinical and molecular parameters in fibromyalgia? Antioxid Redox Signal, 2013. 19(12): p. 1356-61.
  68. Abou-Raya, A., S. Abou-Raya, and M. Helmii, THU0305 Effect of Oral Coenzyme Q10 Supplementation on Clinical Symptoms and Oxidative Stress in Fibromyalgia Patients: A Randomized Trial. Annals Of The Rheumatic Diseases, 2014. 73(Suppl 2): p. 288.
  69. Mohseni, M., et al., Effects of Coenzyme Q10 Supplementation on Serum Lipoproteins, Plasma Fibrinogen, and Blood Pressure in Patients With Hyperlipidemia and Myocardial Infarction. Iranian Red Crescent Medical Journal, 2014. 16: p. e16433.
  70. Hodgson, J.M., et al., Coenzyme Q10 improves blood pressure and glycaemic control: a controlled trial in subjects with type 2 diabetes. Eur J Clin Nutr, 2002. 56(11): p. 1137-42.
  71. Raygan, F., et al., The effects of coenzyme Q10 administration on glucose homeostasis parameters, lipid profiles, biomarkers of inflammation and oxidative stress in patients with metabolic syndrome. European Journal of Nutrition, 2015. 55.
  72. Skarlovnik, A., et al., Coenzyme Q10 supplementation decreases statin-related mild-to-moderate muscle symptoms: a randomized clinical study. Medical Science Monitor : International Medical Journal of Experimental and Clinical Research, 2014. 20: p. 2183-2188.
  73. Kolahdouz Mohammadi, R., et al., The effect of coenzyme Q10 supplementation on metabolic status of type 2 diabetic patients. Minerva Gastroenterol Dietol, 2013. 59(2): p. 231-6.
  74. Fallah, M., et al., Clinical Trial of the Effects of Coenzyme Q10 Supplementation on Biomarkers of Inflammation and Oxidative Stress in Diabetic Hemodialysis Patients. International Journal of Preventive Medicine, 2019. 10.
  75. Zahed, N.-S., M. Ghassami, and H. Nikbakht, Effects of coenzyme Q10 supplementation on C-reactive protein and homocysteine as the inflammatory markers in hemodialysis patients; a randomized clinical trial. Journal of nephropathology, 2016. 5(1): p. 38-43.
  76. El Refaeey, A., A. Selem, and A. Badawy, Combined coenzyme Q10 and clomiphene citrate for ovulation induction in clomiphene-citrate-resistant polycystic ovary syndrome. Reprod Biomed Online, 2014. 29(1): p. 119-24.
  77. Teran, E., et al., Coenzyme Q10 supplementation during pregnancy reduces the risk of pre-eclampsia. Int J Gynaecol Obstet, 2009. 105(1): p. 43-5.
  78. Singh, R., H. Khanna, and A. Niaz, Randomized, Double-blind Placebo-controlled Trial of Coenzyme Q10 in Chronic Renal Failure: Discovery of a New Role. Journal of Nutritional & Environmental Medicine, 2009. 10: p. 281-288.
  79. Rusciani, L., et al., Recombinant interferon α-2b and coenzyme Q10 as a postsurgical adjuvant therapy for melanoma: a 3-year trial with recombinant interferon-α and 5-year follow-up. Melanoma Research, 2007. 17(3): p. 177-183.
  80. Ryo, K., et al., Effects of coenzyme Q10 on salivary secretion. Clin Biochem, 2011. 44(8-9): p. 669-74.
  81. Manthena, S., et al., Effectiveness of CoQ10 Oral Supplements as an Adjunct to Scaling and Root Planing in Improving Periodontal Health. Journal of clinical and diagnostic research : JCDR, 2015. 9(8): p. ZC26-ZC28.
  82. Rozen, T.D., et al., Open label trial of coenzyme Q10 as a migraine preventive. Cephalalgia, 2002. 22(2): p. 137-41.
  83. Dahri, M., et al., Efficacy of coenzyme Q10 for the prevention of migraine in women: A randomized, double-blind, placebo-controlled study. European Journal of Integrative Medicine, 2017. 16: p. 8-14.
  84. Sandor, P., et al., Efficacy of coenzyme Q10 in migraine prophylaxis: A randomized controlled trial. Neurology, 2005. 64: p. 713-5.
  85. Schmelzer, C., et al., Ubiquinol-induced gene expression signatures are translated into reduced erythropoiesis and LDL cholesterol levels in humans. IUBMB Life, 2011. 63: p. 42-8.
  86. Sarmiento, A., et al., Short-term ubiquinol supplementation reduces oxidative stress associated with strenuous exercise in healthy adults: A randomized trial. Biofactors, 2016. 42(6): p. 612-622.
  87. Miyamae, T., et al., Increased oxidative stress and coenzyme Q10 deficiency in juvenile fibromyalgia: amelioration of hypercholesterolemia and fatigue by ubiquinol-10 supplementation. Redox Rep, 2013. 18(1): p. 12-9.
  88. Fukuda, S., et al., Ubiquinol-10 supplementation improves autonomic nervous function and cognitive function in chronic fatigue syndrome. Biofactors, 2016. 42(4): p. 431-40.
  89. Mezawa, M., et al., The reduced form of coenzyme Q10 improves glycemic control in patients with type 2 diabetes: an open label pilot study. Biofactors, 2012. 38(6): p. 416-21.
  90. Thakur, A.S., et al., Effect of Ubiquinol on Serum Reproductive Hormones of Amenorrhic Patients. Indian J Clin Biochem, 2016. 31(3): p. 342-8.
  91. Cakiroglu, B., et al., Ubiquinol effect on sperm parameters in subfertile men who have astheno-teratozoospermia with normal sperm concentration. Nephrourol Mon, 2014. 6(3): p. e16870.
  92. Thakur, A.S., et al., Effect of Ubiquinol Therapy on Sperm Parameters and Serum Testosterone Levels in Oligoasthenozoospermic Infertile Men. J Clin Diagn Res, 2015. 9(9): p. Bc01-3.
  93. Safarinejad, M.R., et al., Effects of the reduced form of coenzyme Q10 (ubiquinol) on semen parameters in men with idiopathic infertility: a double-blind, placebo controlled, randomized study. J Urol, 2012. 188(2): p. 526-31.
  94. Lopez-Pedrera, C., et al., THU0398 Beneficial Effects of in Vivo Ubiquinol Supplementation on Athero-Thrombosis Prevention in Antiphospholipid Syndrome Patients. Preliminary Results of a Clinical Trial. Annals Of The Rheumatic Diseases, 2015. 74: p. 340-341.
  95. Yoritaka, A., et al., Randomized, double-blind, placebo-controlled pilot trial of reduced coenzyme Q10 for Parkinson's disease. Parkinsonism & Related Disorders, 2015. 21(8): p. 911-916.
  96. Kinoshita, T., K. Maruyama, and T. Tanigawa, The Effects of Long-Term Ubiquinol Intake on Improving the Quality of Life of Community Residents. Functional foods in Health and Disease, 2016. 6(1): p. 16-32.
  97. Shoko, D., K. Fujii, and T. Kurihara, The effect of the reduced form of Coenzyme Q10 (ubiquinol, Kaneka QH) on QOL improvement in the elderly. J Clin Therap Med, 2008. 24.
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