References - Clinical Solutions to Repair the Gut Lining References
1. Quigley EMM. Leaky gut - concept or clinical entity. Curr Opin Gastroenterol. 2016 Mar;32(2):74-79. DOI: 10.1097/MOG.0000000000000243
2. Viggiano D, Ianiro G, Vanella G, Bibbò S, Bruno G, Simeone G, et al. Gut barrier in health and disease: focus on childhood. Eur Rev Med Pharmacol Sci. 2015;19(6):1077-1085.
3. Okumura R, Takeda K. Roles of intestinal epithelial cells in the maintenance of gut homeostasis. Exp Mol Med. 2017 May;49(5):e338. DOI: 10.1038/emm.2017.20
4. Zuo L, Kuo WT, Turner JR. Tight junctions as targets and effectors of mucosal immune homeostasis. Cell Mol Gastroenterol Hepatol. 2020;10(2):327-340. DOI: 10.1016/j.jcmgh.2020.04.001
5. König J, Wells J, Cani PD, García-Ródenas CL, MacDonald T, Mercenier A, et al. Human intestinal barrier function in health and disease. Clin Transl Gastroenterol. 2016 Oct;7(10):e196. DOI: 10.1038/ctg.2016.54
6. Guarner F, Khan AG, Garisch J, Eliakim R, Gangl A, Thomson A, et al. World Gastroenterology Organisation Global guidelines: probiotics and prebiotics. J Clin Gastroenterol. 2012 Jul;46(6):468-481. DOI: 10.1097/MCG.0b013e3182549092
7. Rao CV. Regulation of COX and LOX by curcumin. Adv Exp Med Biol. 2007;595:213-226. DOI: 10.1007/978-0-387-46401-5_9
8. Yang R, Yuan BC, Ma YS, Zhou S, Liu Y. The anti-inflammatory activity of licorice, a widely used Chinese herb. Pharm Biol. 2017 Dec;55(1):5-18. DOI: 10.1080/13880209.2016.1225775
9. Chandrasekaran CV, Deepak HB, Thiyagarajan P, Kathiresan S, Sangli GK, Deepak M, et al. Dual inhibitory effect of Glycyrrhiza glabra (GutGard™) on COX and LOX products. Phytomedicine. 2011 Feb;18(4):278-284. DOI: 10.1016/j.phymed.2010.08.001
10. Dion C, Chappuis E, Ripoll C. Does larch arabinogalactan enhance immune function? A review of mechanistic and clinical trials. Nutr Metab (Lond). 2016 Apr;13:28. DOI: 10.1186/s12986-016-0086-x
11. Chen O, Sudakaran S, Blonquist T, Mah E, Durkee S, Bellamine A. Effect of arabinogalactan on the gut microbiome: a randomized, double-blind, placebo-controlled, crossover trial in healthy adults. Nutrition. 2021 Oct;90:111273. DOI: 10.1016/j.nut.2021.111273
12. Kaczmarek JL, Liu X, Charron CS, Novotny JA, Jeffery EH, Seifried HE, et al. Broccoli consumption affects the human gastrointestinal microbiota. J Nutr Biochem. 2019 Jan;63:27-34. DOI: 10.1016/j.jnutbio.2018.09.015
13. Rao R, Samak G. Role of glutamine in protection of intestinal epithelial tight junctions. J Epithel Biol Pharmacol. 2012 Jan;5(Suppl 1-M7):47-54. DOI: 10.2174/1875044301205010047
14. Bischoff SC, Barbara G, Buurman W, Ockhuizen T, Schulzke JD, Serino M, et al. Intestinal permeability--a new target for disease prevention and therapy. BMC Gastroenterol. 2014 Nov;14:189. DOI: 10.1186/s12876-014-0189-7
15. Shao Y, Wolf PG, Guo S, Guo Y, Gaskins HR, Zhang B. Zinc enhances intestinal epithelial barrier function through the PI3K/AKT/mTOR signaling pathway in Caco-2 cells. J Nutr Biochem. 2017 May;43:18-26. DOI: 10.1016/j.jnutbio.2017.01.013
16. National Health and Medical Research Council. Nutrient reference values for Australia and New Zealand including recommended dietary intakes [Internet]. Canberra ACT: National Health and Medical Research Council; 2006 [cited 2022 Mar 8]. 320 p. Available from: https://www.nhmrc.gov.au/sites/default/files/images/nutrient-refererence-dietary-intakes.pdf
17. Natural Medicines Database [Internet]. Denver CO: TRC Healthcare; 2021. Kiwi; 2021 Apr [cited 2022 Mar 8]. Available from: https://naturalmedicines.therapeuticresearch.com/databases/food,-herbs-supplements/professional.aspx?productid=944
18. Omar HR, Komarova I, El-Ghonemi M, Fathy A, Rashad R, Abdelmalak HD, et al. Licorice abuse: time to send a warning message. Ther Adv Endocrinol Metab. 2012 Aug;3(4):125-138. DOI: 10.1177/2042018812454322
19. Ralston SH, Penman I, Strachan M, Hobson R. Davidson’s principles and practice of medicine. 23rd ed. Edinburgh (UK): Elsevier/Churchill Livingstone; 2018. p.297.
20. Kiela PR, Ghishan FK. Physiology of intestinal absorption and secretion. Best Pract Res Clin Gastroenterol. 2016 Apr;30(2):145-159. DOI: 10.1016/j.bpg.2016.02.007
21. Niv Y, Fass R. The role of mucin in GERD and its complications. Nat Rev Gastroenterol Hepatol. 2011 Nov;9(1):55-59. DOI: 10.1038/nrgastro.2011.211
22. Allen A, Flemström G. Gastroduodenal mucus bicarbonate barrier: protection against acid and pepsin. Am J Physiol Cell Physiol. 2005 Jan;288(1):C1-19. DOI: 10.1152/ajpcell.00102.2004
23. Stagg AJ, Hart AL, Knight SC, Kamm MA. The dendritic cell: its role in intestinal inflammation and relationship with gut bacteria. Gut. 2003 Oct;52(10):1522-1529. DOI: 10.1136/gut.52.10.1522
24. Costa M, Brookes SJ, Hennig GW. Anatomy and physiology of the enteric nervous system. Gut. 2000 Dec;47 Suppl 4:iv15-9; discussion iv26. DOI: 10.1136/gut.47.suppl_4.iv15
25. Silva YP, Bernardi A, Frozza RL. The role of short-chain fatty acids from gut microbiota in gut-brain communication. Front Endocrinol (Lausanne). 2020;11:25. DOI: 10.3389/fendo.2020.00025
26. Martin CR, Osadchiy V, Kalani A, Mayer EA. The brain-gut-microbiome axis. Cell Mol Gastroenterol Hepatol. 2018;6(2):133-148. DOI: 10.1016/j.jcmgh.2018.04.003
27. Bonaz B, Bazin T, Pellissier S. The vagus nerve at the interface of the microbiota-gut-brain axis. Front Neurosci. 2018;12:49. DOI: 10.3389/fnins.2018.00049
28. Becker JC, Domschke W, Pohle T. Current approaches to prevent NSAID-induced gastropathy--COX selectivity and beyond. Br J Clin Pharmacol. 2004 Dec;58(6):587-600. DOI: 10.1111/j.1365-2125.2004.02198.x
29. Wallace JL. Prostaglandins, NSAIDs, and gastric mucosal protection: why doesn't the stomach digest itself. Physiol Rev. 2008 Oct;88(4):1547-1565. DOI: 10.1152/physrev.00004.2008
30. Wallace JL. How do NSAIDs cause ulcer disease. Baillieres Best Pract Res Clin Gastroenterol. 2000 Feb;14(1):147-159. DOI: 10.1053/bega.1999.0065
31. Jian Y, Zhang D, Liu M, Wang Y, Xu ZX. The impact of gut microbiota on radiation-induced enteritis. Front Cell Infect Microbiol. 2021;11:586392. DOI: 10.3389/fcimb.2021.586392
32. Liu J, Liu C, Yue J. Radiotherapy and the gut microbiome: facts and fiction. Radiat Oncol. 2021 Jan;16(1):9. DOI: 10.1186/s13014-020-01735-9
33. Montassier E, Gastinne T, Vangay P, Al-Ghalith GA, Bruley Des Varannes S, Massart S, et al. Chemotherapy-driven dysbiosis in the intestinal microbiome. Aliment Pharmacol Ther. 2015 Sep;42(5):515-528. DOI: 10.1111/apt.13302
34. Yang J, Wang HP, Zhou L, Xu CF. Effect of dietary fiber on constipation: a meta analysis. World J Gastroenterol. 2012 Dec;18(48):7378-7383. DOI: 10.3748/wjg.v18.i48.7378
35. Voderholzer WA, Schatke W, Mühldorfer BE, Klauser AG, Birkner B, Müller-Lissner SA. Clinical response to dietary fiber treatment of chronic constipation. Am J Gastroenterol. 1997 Jan;92(1):95-98.
36. Brownlee IA. The physiological roles of dietary fibre. Food Hydrocolloids. 2011 Mar;25(2):238–250. DOI: 10.1016/j.foodhyd.2009.11.013
37. Chaplin MF. Fibre and water binding. Proc Nutr Soc. 2003 Feb;62(1):223-227. DOI: 10.1079/pns2002203
38. Müller M, Canfora EE, Blaak EE. Gastrointestinal transit time, glucose homeostasis and metabolic health: modulation by dietary fibers. Nutrients. 2018 Feb;10(3):E275. DOI: 10.3390/nu10030275
39. Hillemeier C. An overview of the effects of dietary fiber on gastrointestinal transit. Pediatrics. 1995 Nov;96(5 Pt 2):997-999.
40. Mathias M. Autointoxication and historical precursors of the microbiome-gut-brain axis. Microb Ecol Health Dis. 2018 Nov;29(2):1548249. DOI: 10.1080/16512235.2018.1548249
41. Chassard C, Dapoigny M, Scott KP, Crouzet L, Del'homme C, Marquet P, et al. Functional dysbiosis within the gut microbiota of patients with constipated-irritable bowel syndrome. Aliment Pharmacol Ther. 2012 Apr;35(7):828-838. DOI: 10.1111/j.1365-2036.2012.05007.x
42. Guan ZW, Yu EZ, Feng Q. Soluble dietary fiber, one of the most important nutrients for the gut microbiota. Molecules. 2021 Nov;26(22):6802. DOI: 10.3390/molecules26226802
43. Deleu S, Machiels K, Raes J, Verbeke K, Vermeire S. Short chain fatty acids and its producing organisms: An overlooked therapy for IBD. EBioMedicine. 2021 Apr;66:103293. DOI: 10.1016/j.ebiom.2021.103293
44. Mao G, Li S, Orfila C, Shen X, Zhou S, Linhardt RJ, et al. Depolymerized RG-I-enriched pectin from citrus segment membranes modulates gut microbiota, increases SCFA production, and promotes the growth of Bifidobacterium spp., Lactobacillus spp. and Faecalibaculum spp. Food Funct. 2019 Dec;10(12):7828-7843. DOI: 10.1039/c9fo01534e
45. Lauret E, Rodrigo L. Celiac disease and autoimmune-associated conditions. Biomed Res Int. 2013;2013:127589. DOI: 10.1155/2013/127589
46. Cardoso-Silva D, Delbue D, Itzlinger A, Moerkens R, Withoff S, Branchi F, et al. Intestinal barrier function in gluten-related disorders. Nutrients. 2019 Oct;11(10):E2325. DOI: 10.3390/nu11102325
47. Camilleri M. Leaky gut: mechanisms, measurement and clinical implications in humans. Gut. 2019 Aug;68(8):1516-1526. DOI: 10.1136/gutjnl-2019-318427
48. Schumann M, Siegmund B, Schulzke JD, Fromm M. Celiac disease: role of the epithelial barrier. Cell Mol Gastroenterol Hepatol. 2017 Mar;3(2):150-162. DOI: 10.1016/j.jcmgh.2016.12.006
49. Ulitsky A, Ananthakrishnan AN, Naik A, Skaros S, Zadvornova Y, Binion DG, et al. Vitamin D deficiency in patients with inflammatory bowel disease: association with disease activity and quality of life. JPEN J Parenter Enteral Nutr. 2011 May;35(3):308-316. DOI: 10.1177/0148607110381267
50. Skrovanek S, DiGuilio K, Bailey R, Huntington W, Urbas R, Mayilvaganan B, et al. Zinc and gastrointestinal disease. World J Gastrointest Pathophysiol. 2014 Nov 15;5(4):496-513. DOI: 10.4291/wjgp.v5.i4.496
51. Wierdsma NJ, Van Bokhorst-De Van Der Schueren MA, Berkenpas M, Mulder CJ, Van Bodegraven AA. Vitamin and mineral deficiencies are highly prevalent in newly diagnosed celiac disease patients. Nutrients. 2013 Sep;5(10):3975-3592. DOI: 10.3390/nu5103975
52. Fabisiak N, Fabisiak A, Watala C, Fichna J. Fat-soluble vitamin deficiencies and inflammatory bowel disease: systematic review and meta-analysis. J Clin Gastroenterol. 2017 Nov/Dec;51(10):878-889. DOI: 10.1097/MCG.0000000000000911
53. Soares-Mota M, Silva TA, Gomes LM, Pinto MAS, Mendonça LMC, Farias MLF, et al. High prevalence of vitamin A deficiency in Crohn's disease patients according to serum retinol levels and the relative dose-response test. World J Gastroenterol. 2015 Feb;21(5):1614-1620. DOI: 10.3748/wjg.v21.i5.1614
54. Mora JR, Iwata M, Von Andrian UH. Vitamin effects on the immune system: vitamins A and D take centre stage. Nat Rev Immunol. 2008 Sep;8(9):685-698. DOI: 10.1038/nri2378
55. Ramirez J, Guarner F, Bustos Fernandez L, Maruy A, Sdepanian VL, Cohen H. Antibiotics as major disruptors of gut microbiota. Front Cell Infect Microbiol. 2020;10:572912. DOI: 10.3389/fcimb.2020.572912
56. Le Bastard Q, Al-Ghalith GA, Grégoire M, Chapelet G, Javaudin F, Dailly E, et al. Systematic review: human gut dysbiosis induced by non-antibiotic prescription medications. Aliment Pharmacol Ther. 2018 Feb;47(3):332-345. DOI: 10.1111/apt.14451
57. Martinez JE, Kahana DD, Ghuman S, Wilson HP, Wilson J, Kim SCJ, et al. Unhealthy lifestyle and gut dysbiosis: a better understanding of the effects of poor diet and nicotine on the intestinal microbiome. Front Endocrinol (Lausanne). 2021;12:667066. DOI: 10.3389/fendo.2021.667066
58. Mutlu E, Keshavarzian A, Engen P, Forsyth CB, Sikaroodi M, Gillevet P. Intestinal dysbiosis: a possible mechanism of alcohol-induced endotoxemia and alcoholic steatohepatitis in rats. Alcohol Clin Exp Res. 2009 Oct;33(10):1836-1846. DOI: 10.1111/j.1530-0277.2009.01022.x
59. Matenchuk BA, Mandhane PJ, Kozyrskyj AL. Sleep, circadian rhythm, and gut microbiota. Sleep Med Rev. 2020 Oct;53:101340. DOI: 10.1016/j.smrv.2020.101340
60. McColl KE, El-Omar E, Gillen D. Helicobacter pylori gastritis and gastric physiology. Gastroenterol Clin North Am. 2000 Sep;29(3):687-703. DOI: 10.1016/s0889-8553(05)70138-2
61. Issa M, Ananthakrishnan AN, Binion DG. Clostridium difficile and inflammatory bowel disease. Inflamm Bowel Dis. 2008 Oct;14(10):1432-1442. DOI: 10.1002/ibd.20500
62. Kurtz JR, Goggins JA, McLachlan JB. Salmonella infection: Interplay between the bacteria and host immune system. Immunol Lett. 2017 Oct;190:42-50. DOI: 10.1016/j.imlet.2017.07.006
63. Glass RI, Parashar UD, Estes MK. Norovirus gastroenteritis. N Engl J Med. 2009 Oct;361(18):1776-1785. DOI: 10.1056/NEJMra0804575
64. De La Cabada Bauche J, Dupont HL. New developments in traveler's diarrhea. Gastroenterol Hepatol (N Y). 2011 Feb;7(2):88-95.
65. Engevik MA, Yacyshyn MB, Engevik KA, Wang J, Darien B, Hassett DJ, et al. Human Clostridium difficile infection: altered mucus production and composition. Am J Physiol Gastrointest Liver Physiol. 2015 Mar;308(6):G510-524. DOI: 10.1152/ajpgi.00091.2014
66. Smoot DT. How does Helicobacter pylori cause mucosal damage? Direct mechanisms. Gastroenterology. 1997 Dec;113(6 Suppl):S31-43; discussion S50. DOI: 10.1016/s0016-5085(97)80008-x
67. Del Pinto R, Ferri C, Cominelli F. Vitamin D axis in inflammatory bowel diseases: role, current uses and future perspectives. Int J Mol Sci. 2017 Nov;18(11):E2360. DOI: 10.3390/ijms18112360
68. Gesensway D. Vitamin D. Ann Intern Med. 2000 Aug;133(4):319-320.
69. Yin K, Agrawal DK. Vitamin D and inflammatory diseases. J Inflamm Res. 2014;7:69-87.
70. Kamen DL, Tangpricha V. Vitamin D and molecular actions on the immune system: modulation of innate and autoimmunity. J Mol Med (Berl). 2010 May;88(5):441-450. DOI: 10.1007/s00109-010-0590-9
71. Du J, Chen Y, Shi Y, Liu T, Cao Y, Tang Y, et al. 1,25-dihydroxyvitamin D protects intestinal epithelial barrier by regulating the myosin light chain kinase signaling pathway. Inflamm Bowel Dis. 2015 Nov;21(11):2495-2506. DOI: 10.1097/MIB.0000000000000526
72. Barbalho SM, Goulart RA, Gasparini RG. Associations between inflammatory bowel diseases and vitamin D. Crit Rev Food Sci Nutr. 2019;59(8):1347-1356. DOI: 10.1080/10408398.2017.1406333
73. Shi Y, Liu T, Zhao X, Yao L, Hou A, Fu J, et al. Vitamin D ameliorates neonatal necrotizing enterocolitis via suppressing TLR4 in a murine model. Pediatr Res. 2018 May;83(5):1024-1030. DOI: 10.1038/pr.2017.329
74. Prietl B, Treiber G, Pieber TR, Amrein K. Vitamin D and immune function. Nutrients. 2013 Jul;5(7):2502-2521. DOI: 10.3390/nu5072502
75. Vici G, Camilletti D, Polzonetti V. Possible role of vitamin D in celiac disease onset. Nutrients. 2020 Apr;12(4):E1051. DOI: 10.3390/nu12041051
76. Assa A, Vong L, Pinnell LJ, Avitzur N, Johnson-Henry KC, Sherman PM. Vitamin D deficiency promotes epithelial barrier dysfunction and intestinal inflammation. J Infect Dis. 2014 Oct;210(8):1296-1305. DOI: 10.1093/infdis/jiu235
77. Sun J. Vitamin D and mucosal immune function. Curr Opin Gastroenterol. 2010 Nov;26(6):591-595. DOI: 10.1097/MOG.0b013e32833d4b9f
78. Duncan M, Grant G. Oral and intestinal mucositis - causes and possible treatments. Aliment Pharmacol Ther. 2003 Nov;18(9):853-874. DOI: 10.1046/j.1365-2036.2003.01784.x
79. Kim H. Glutamine as an immunonutrient. Yonsei Med J. 2011 Nov;52(6):892-897. DOI: 10.3349/ymj.2011.52.6.892
80. Quan ZF, Yang C, Li N, Li JS. Effect of glutamine on change in early postoperative intestinal permeability and its relation to systemic inflammatory response. World J Gastroenterol. 2004 Jul;10(13):1992-1994. DOI: 10.3748/wjg.v10.i13.1992
81. Scheppach W, Loges C, Bartram P, Christl SU, Richter F, Dusel G, et al. Effect of free glutamine and alanyl-glutamine dipeptide on mucosal proliferation of the human ileum and colon. Gastroenterology. 1994 Aug;107(2):429-434. DOI: 10.1016/0016-5085(94)90168-6
82. Mondello S, Italiano D, Giacobbe MS, Mondello P, Trimarchi G, Aloisi C, et al. Glutamine-supplemented total parenteral nutrition improves immunological status in anorectic patients. Nutrition. 2010 Jun;26(6):677-681. DOI: 10.1016/j.nut.2009.10.008
83. Peng X, Yan H, You Z, Wang P, Wang S. Glutamine granule-supplemented enteral nutrition maintains immunological function in severely burned patients. Burns. 2006 Aug;32(5):589-593. DOI: 10.1016/j.burns.2005.11.020
84. Duggan C, Gannon J, Walker WA. Protective nutrients and functional foods for the gastrointestinal tract. Am J Clin Nutr. 2002 May;75(5):789-808. DOI: 10.1093/ajcn/75.5.789
85. Shankar AH, Prasad AS. Zinc and immune function: the biological basis of altered resistance to infection. Am J Clin Nutr. 1998 Aug;68(2 Suppl):447S-463S. DOI: 10.1093/ajcn/68.2.447S
86. Ye MB, Lim BO. Dietary pectin regulates the levels of inflammatory cytokines and immunoglobulins in interleukin-10 knockout mice. J Agric Food Chem. 2010 Nov;58(21):11281-11286. DOI: 10.1021/jf103262s
87. Richardson DP, Ansell J, Drummond LN. The nutritional and health attributes of kiwifruit: a review. Eur J Nutr. 2018 Dec;57(8):2659-2676. DOI: 10.1007/s00394-018-1627-z
88. Edmunds SJ, Roy NC, Love DR, Laing WA. Kiwifruit extracts inhibit cytokine production by lipopolysaccharide-activated macrophages, and intestinal epithelial cells isolated from IL10 gene deficient mice. Cell Immunol. 2011;270(1):70-79. DOI: 10.1016/j.cellimm.2011.04.004
89. Amara AA, Shibl A. Role of Probiotics in health improvement, infection control and disease treatment and management. Saudi Pharm J. 2015 Apr;23(2):107-114. DOI: 10.1016/j.jsps.2013.07.001
90. Vieira AT, Teixeira MM, Martins FS. The role of probiotics and prebiotics in inducing gut immunity. Front Immunol. 2013 Dec;4:445. DOI: 10.3389/fimmu.2013.00445
91. Udani JK. Immunomodulatory effects of ResistAid™: A randomized, double-blind, placebo-controlled, multidose study. J Am Coll Nutr. 2013;32(5):331-338. DOI: 10.1080/07315724.2013.839907
92. Robinson RR, Feirtag J, Slavin JL. Effects of dietary arabinogalactan on gastrointestinal and blood parameters in healthy human subjects. J Am Coll Nutr. 2001 Aug;20(4):279-285. DOI: 10.1080/07315724.2001.10719048
93. Thorne Research, Inc. Larch arabinogalactan. Altern Med Rev. 2000;5(5):463.
94. Taylor RA, Leonard MC. Curcumin for inflammatory bowel disease: a review of human studies. Altern Med Rev. 2011 Jun;16(2):152-156.
95. Wang J, Ghosh SS, Ghosh S. Curcumin improves intestinal barrier function: modulation of intracellular signaling, and organization of tight junctions. Am J Physiol Cell Physiol. 2017 Apr;312(4):C438-C445. DOI: 10.1152/ajpcell.00235.2016
96. Yadav SK, Sah AK, Jha RK, Sah P, Shah DK. Turmeric (curcumin) remedies gastroprotective action. Pharmacogn Rev. 2013 Jan;7(13):42-46. DOI: 10.4103/0973-7847.112843
97. Braun L, Cohen M, Arthur R, Fox G, McEwen B, Oates L, et al. Herbs & natural supplements, volume 2: an evidence-based guide. 4th ed. Sydney: Churchill Livingstone; 2015. 1362 p.
98. Raveendra KR, Jayachandra, Srinivasa V, Sushma KR, Allan JJ, Goudar KS, et al. An extract of glycyrrhiza glabra (GutGard) alleviates symptoms of functional dyspepsia: a randomized, double-blind, placebo-controlled study. Evid Based Complement Alternat Med. 2012;2012:216970. DOI: 10.1155/2012/216970
99. Mukherjee M, Bhaskaran N, Srinath R, Shivaprasad HN, Allan JJ, Shekhar D, et al. Anti-ulcer and antioxidant activity of GutGard. Indian J Exp Biol. 2010 Mar;48(3):269-274.
100. Guslandi M. Ulcer-healing drugs and endogenous prostaglandins. Int J Clin Pharmacol Ther Toxicol. 1985 Aug;23(8):398-402.
101. Van Marle J, Aarsen PN, Lind A, Van Weeren-Kramer J. Deglycyrrhizinised liquorice (DGL) and the renewal of rat stomach epithelium. Eur J Pharmacol. 1981 Jun;72(2-3):219-225. DOI: 10.1016/0014-2999(81)90276-4
102. Puram S, Suh HC, Kim SU, Bethapudi B, Joseph JA, Agarwal A, et al. Effect of GutGard in the management of Helicobacter pylori: a randomized double blind placebo controlled study. Evid Based Complement Alternat Med. 2013;2013:263805. DOI: 10.1155/2013/263805
103. Skinner MA, Loh JM, Hunter DC, Zhang J. Gold kiwifruit ( Actinidia chinensis 'Hort16A') for immune support. Proc Nutr Soc. 2011 May;70(2):276-280. DOI: 10.1017/S0029665111000048
104. Moughan PJ, Rutherfurd SM, Balan P. Kiwifruit, mucins, and the gut barrier. Adv Food Nutr Res. 2013;68:169-185. DOI: 10.1016/B978-0-12-394294-4.00009-2
105. Amer M, Eid J, Hamad SR. Evaluation of gastric and hepatic protective effects of kiwifruit extract on toxicity of indomethacin in Swiss albino mice using histological studies. IJSR. 2014 Jul;3(7).
106. Lee YK, Low KY, Siah K, Drummond LM, Gwee KA. Kiwifruit (Actinidia deliciosa) changes intestinal microbial profile. Microb Ecol Health Dis. 2012;23. DOI: 10.3402/mehd.v23i0.18572
107. Budai MM, Varga A, Milesz S, Tőzsér J, Benkő S. Aloe vera downregulates LPS-induced inflammatory cytokine production and expression of NLRP3 inflammasome in human macrophages. Mol Immunol. 2013 Dec;56(4):471-479. DOI: 10.1016/j.molimm.2013.05.005
108. Sahu PK, Giri DD, Singh R, Pandey P, Gupta S, Kumar A, et al. Therapeutic and medicinal uses of Aloe vera: a review. Pharmacol Pharma. 2013 Nov;4(8):599-610. DOI: 10.4236/pp.2013.48086
109. Park MY, Kwon HJ, Sung MK. Evaluation of aloin and aloe-emodin as anti-inflammatory agents in aloe by using murine macrophages. Biosci Biotechnol Biochem. 2009 Apr;73(4):828-832. DOI: 10.1271/bbb.80714
110. Mukherjee PK, Nema NK, Maity N, Mukherjee K, Harwansh RK. Phytochemical and therapeutic profile of Aloe vera. J Nat Remedies. 2014 Jan;14(1):1-26. DOI: 10.18311/jnr/2014/84
111. Eamlamnam K, Patumraj S, Visedopas N, Thong-Ngam D. Effects of Aloe vera and sucralfate on gastric microcirculatory changes, cytokine levels and gastric ulcer healing in rats. World J Gastroenterol. 2006 Apr;12(13):2034-2039. DOI: 10.3748/wjg.v12.i13.2034
112. Jain S, Mujoo S, Daga M, Kalra S, Nagi R, Laheji A. Comparison of antifungal effect of Aloevera gel and triphala: an in vitro study. J Indian Acad Oral Med Radiol. 2017;29(2):90-94. DOI: 10.4103/jiaomr.JIAOMR_167_16
113. Radha MH, Laxmipriya NP. Evaluation of biological properties and clinical effectiveness of Aloe vera: a systematic review. J Tradit Complement Med. 2015 Jan;5(1):21-26. DOI: 10.1016/j.jtcme.2014.10.006
114. Chang YW, Jang JY, Kim YH, Kim JW, Shim JJ. The effects of broccoli sprout extract containing sulforaphane on lipid peroxidation and helicobacter pylori infection in the gastric mucosa. Gut Liver. 2015 Jul;9(4):486-493. DOI: 10.5009/gnl14040
115. Kaczmarek JL, Charron CS, Novotny JA, Jeffery EH, Seifried H, Ross SA, et al. Broccoli consumption impacts the human gastrointestinal microbiota. FASEB J. 2018 Oct;31(S1):965.18-965.18. DOI: 10.1096/fasebj.31.1_supplement.965.18
116. Yanaka A. Role of sulforaphane in protection of gastrointestinal tract against H. pylori and NSAID-induced oxidative stress. Curr Pharm Des. 2017;23(27):4066-4075. DOI: 10.2174/1381612823666170207103943
117. Zhang Y, Tan L, Li C, Wu H, Ran D, Zhang Z. Sulforaphane alter the microbiota and mitigate colitis severity on mice ulcerative colitis induced by DSS. AMB Express. 2020 Jul;10(1):119. DOI: 10.1186/s13568-020-01053-z
118. Koloski NA, Jones M, Talley NJ. Evidence that independent gut-to-brain and brain-to-gut pathways operate in the irritable bowel syndrome and functional dyspepsia: a 1-year population-based prospective study. Aliment Pharmacol Ther. 2016 Sep;44(6):592-600. DOI: 10.1111/apt.13738
119. Dupont HL. Review article: evidence for the role of gut microbiota in irritable bowel syndrome and its potential influence on therapeutic targets. Aliment Pharmacol Ther. 2014 May;39(10):1033-1042. DOI: 10.1111/apt.12728
120. Zhou Q, Verne ML, Fields JZ, Lefante JJ, Basra S, Salameh H, et al. Randomised placebo-controlled trial of dietary glutamine supplements for postinfectious irritable bowel syndrome. Gut. 2019 Jun;68(6):996-1002. DOI: 10.1136/gutjnl-2017-315136
121. Bundy R, Walker AF, Middleton RW, Booth J. Turmeric extract may improve irritable bowel syndrome symptomology in otherwise healthy adults: a pilot study. J Altern Complement Med. 2004 Dec;10(6):1015-1018. DOI: 10.1089/acm.2004.10.1015
122. Talley NJ, Goodsall T, Potter M. Functional dyspepsia. Aust Prescr. 2017 Dec;40(6):209-213. DOI: 10.18773/austprescr.2017.066
123. Panahi Y, Karbasi A, Valizadegan G, Ostadzadeh N, Soflaei SS, Jamialahmadi T, et al. Effect of curcumin on severity of functional dyspepsia: a triple blinded clinical trial. Adv Exp Med Biol. 2021;1308:119-126. DOI: 10.1007/978-3-030-64872-5_10
124. Ni J, Wu GD, Albenberg L, Tomov VT. Gut microbiota and IBD: causation or correlation. Nat Rev Gastroenterol Hepatol. 2017 Oct;14(10):573-584. DOI: 10.1038/nrgastro.2017.88
125. Shim JO. Gut microbiota in inflammatory bowel disease. Pediatr Gastroenterol Hepatol Nutr. 2013 Mar;16(1):17-21. DOI: 10.5223/pghn.2013.16.1.17
126. Chiu HF, Venkatakrishnan K, Golovinskaia O, Wang CK. Gastroprotective effects of polyphenols against various gastro-intestinal disorders: a mini-review with special focus on clinical evidence. Molecules. 2021 Apr;26(7):2090. DOI: 10.3390/molecules26072090
127. Sadeghi N, Mansoori A, Shayesteh A, Hashemi SJ. The effect of curcumin supplementation on clinical outcomes and inflammatory markers in patients with ulcerative colitis. Phytother Res. 2020 May;34(5):1123-1133. DOI: 10.1002/ptr.6581
128. Lang A, Salomon N, Wu JC, Kopylov U, Lahat A, Har-Noy O, et al. Curcumin in combination with mesalamine induces remission in patients with mild-to-moderate ulcerative colitis in a randomized controlled trial. Clin Gastroenterol Hepatol. 2015 Aug;13(8):1444-9.e1. DOI: 10.1016/j.cgh.2015.02.019
129. Sakurai K, Furukawa S, Katsurada T, Otagiri S, Yamanashi K, Nagashima K, et al. Effectiveness of administering zinc acetate hydrate to patients with inflammatory bowel disease and zinc deficiency: a retrospective observational two-center study. Intest Res. 2022 Jan;20(1):78-89. DOI: 10.5217/ir.2020.00124
130. Karimi S, Tabataba-Vakili S, Yari Z, Alborzi F, Hedayati M, Ebrahimi-Daryani N, et al. The effects of two vitamin D regimens on ulcerative colitis activity index, quality of life and oxidant/anti-oxidant status. Nutr J. 2019 Mar;18(1):16. DOI: 10.1186/s12937-019-0441-7
131. Lu Y, Li X, Liu S, Zhang Y, Zhang D. Toll-like receptors and inflammatory bowel disease. Front Immunol. 2018;9:72. DOI: 10.3389/fimmu.2018.00072
132. Caio G, Volta U, Sapone A, Leffler DA, De Giorgio R, Catassi C, et al. Celiac disease: a comprehensive current review. BMC Med. 2019;17(1):142. DOI: 10.1186/s12916-019-1380-z
133. De Palma G, Nadal I, Medina M, Donat E, Ribes-Koninckx C, Calabuig M, et al. Intestinal dysbiosis and reduced immunoglobulin-coated bacteria associated with coeliac disease in children. BMC Microbiol. 2010 Feb;10:63. DOI: 10.1186/1471-2180-10-63
134. Jayawardana IA, Boland MJ, Higgs K, Zou M, Loo T, Mcnabb WC, et al. The kiwifruit enzyme actinidin enhances the hydrolysis of gluten proteins during simulated gastrointestinal digestion. Food Chem. 2021 Mar;341(Pt 1):128239. DOI: 10.1016/j.foodchem.2020.128239
135. Ciardiello MA, Meleleo D, Saviano G, Crescenzo R, Carratore V, Camardella L, et al. Kissper, a kiwi fruit peptide with channel-like activity: structural and functional features. J Pept Sci. 2008 Jun;14(6):742-754. DOI: 10.1002/psc.992
136. Fathi F, Ektefa F, Tafazzoli M, Rostami K, Rostami Nejad M, Fathi M, et al. The concentration of serum zinc in celiac patients compared to healthy subjects in Tehran. Gastroenterol Hepatol Bed Bench. 2013;6(2):92-95.
137. Högberg L, Danielsson L, Jarleman S, Sundqvist T, Stenhammar L. Serum zinc in small children with coeliac disease. Acta Paediatr. 2009 Feb;98(2):343-345. DOI: 10.1111/j.1651-2227.2008.01085.x
138. Deora V, Aylward N, Sokoro A, El-Matary W. Serum vitamins and minerals at diagnosis and follow-up in children with celiac disease. J Pediatr Gastroenterol Nutr. 2017 Aug;65(2):185-189. DOI: 10.1097/MPG.0000000000001475
139. De Giorgi F, Palmiero M, Esposito I, Mosca F, Cuomo R. Pathophysiology of gastro-oesophageal reflux disease. Acta Otorhinolaryngol Ital. 2006 Oct;26(5):241-246.
140. Kwiecien S, Magierowski M, Majka J, Ptak-Belowska A, Wojcik D, Sliwowski Z, et al. Curcumin: a potent protectant against esophageal and gastric disorders. Int J Mol Sci. 2019 Mar;20(6):E1477. DOI: 10.3390/ijms20061477
141. O'Sullivan-Coyne G, O'Sullivan GC, O'Donovan TR, Piwocka K, McKenna SL. Curcumin induces apoptosis-independent death in oesophageal cancer cells. Br J Cancer. 2009 Nov;101(9):1585-1595. DOI: 10.1038/sj.bjc.6605308
142. Kusters JG, van Vliet AH, Kuipers EJ. Pathogenesis of Helicobacter pylori infection. Clin Microbiol Rev. 2006 Jul;19(3):449-490. DOI: 10.1128/CMR.00054-05
143. Sachs G, Scott DR, Wen Y. Gastric infection by Helicobacter pylori. Curr Gastroenterol Rep. 2011 Dec;13(6):540-546. DOI: 10.1007/s11894-011-0226-4
144. Celli JP, Turner BS, Afdhal NH, Keates S, Ghiran I, Kelly CP, et al. Helicobacter pylori moves through mucus by reducing mucin viscoelasticity. Proc Natl Acad Sci U S A. 2009 Aug;106(34):14321-14326. DOI: 10.1073/pnas.0903438106
145. Lin YT, Kwon YI, Labbe RG, Shetty K. Inhibition of Helicobacter pylori and associated urease by oregano and cranberry phytochemical synergies. Appl Environ Microbiol. 2005 Dec;71(12):8558-8564. DOI: 10.1128/AEM.71.12.8558-8564.2005
146. Di Giulio M, Di Campli E, Di Bartolomeo S, Cataldi V, Marzio L, Grossi L, et al. In vitro antimicrobial susceptibility of Helicobacter pylori to nine antibiotics currently used in Central Italy. Scand J Gastroenterol. 2016 Mar;51(3):263-269. DOI: 10.3109/00365521.2015.1092577
147. Cellini L, Di Bartolomeo S, Di Campli E, Genovese S, Locatelli M, Di Giulio M. In vitro activity of Aloe vera inner gel against Helicobacter pylori strains. Lett Appl Microbiol. 2014 Jul;59(1):43-48. DOI: 10.1111/lam.12241
148. Hond ED, Peeters M, Hiele M, Bulteel V, Ghoos Y, Rutgeerts P. Effect of glutamine on the intestinal permeability changes induced by indomethacin in humans. Aliment Pharmacol Ther. 1999 May;13(5):679-685. DOI: 10.1046/j.1365-2036.1999.00523.x
149. Benjamin J, Makharia G, Ahuja V, Anand Rajan KD, Kalaivani M, Gupta SD, et al. Glutamine and whey protein improve intestinal permeability and morphology in patients with Crohn's disease: a randomized controlled trial. Dig Dis Sci. 2012 Apr;57(4):1000-1012. DOI: 10.1007/s10620-011-1947-9
150. Langmead L, Feakins RM, Goldthorpe S, Holt H, Tsironi E, De Silva A, et al. Randomized, double-blind, placebo-controlled trial of oral aloe vera gel for active ulcerative colitis. Aliment Pharmacol Ther. 2004 Apr;19(7):739-747. DOI: 10.1111/j.1365-2036.2004.01902.x
151. Ansell J, Butts CA, Paturi G, Eady SL, Wallace AJ, Hedderley D, et al. Kiwifruit-derived supplements increase stool frequency in healthy adults: a randomized, double-blind, placebo-controlled study. Nutr Res. 2015 May;35(5):401-408. DOI: 10.1016/j.nutres.2015.04.005
152. Pang B, Jin H, Liao N, Li J, Jiang C, Shi J. Vitamin A supplementation ameliorates ulcerative colitis in gut microbiota-dependent manner. Food Res Int. 2021 10;148:110568. DOI: 10.1016/j.foodres.2021.110568
153. Chung WS, Walker AW, Louis P, Parkhill J, Vermeiren J, Bosscher D, et al. Modulation of the human gut microbiota by dietary fibres occurs at the species level. BMC Biol. 2016 Jan;14:3. DOI: 10.1186/s12915-015-0224-3