PELI Logo
title

References - Clinical Applications of Zinc and Vitamin C

  1. Simone II CB, Simone NL, Simone V, Simone CB. Antioxidants and other nutrients do not interfere with chemotherapy or radiation therapy and can increase kill and increase survival, Part 2. Alternative therapies in health and medicine. 2007 Jan 1;13(2):40-7.
  2. Reddy DR, Khurana A, Bale S, Ravirala R, Reddy VS, Mohankumar M, Godugu C. Natural flavonoids silymarin and quercetin improve the brain distribution of co-administered P-gp substrate drugs. SpringerPlus. 2016 Dec;5(1):1-9.
  3. Ferraro PM, Curhan GC, Gambaro G, Taylor EN. Total, dietary, and supplemental vitamin C intake and risk of incident kidney stones. American Journal of Kidney Diseases. 2016 Mar 1;67(3):400-7.
  4. Braun L, Cohen M. Herbs & Natural Supplements. Churchill Livingstone: Sydney, 2007.
  5. Higdon J, Drake VJ. http://lpi.oregonstate.edu/mic/minerals/manganese. Accessed 18 April 2017.
  6. Hemilä H. Vitamin C and infections. Nutrients. 2017 Mar 29;9(4):339.
  7. West CE, Dunstan J, McCarthy S, Metcalfe J, D’Vaz N, Meldrum S, Oddy WH, Tulic MK, Prescott SL. Associations between maternal antioxidant intakes in pregnancy and infant allergic outcomes. Nutrients. 2012 Nov 14;4(11):1747-58.
  8. MacKay DJ, Miller AL. Nutritional support for wound healing. Alternative medicine review. 2003 Nov 1;8(4).
  9. Harrison FE, May JM. Vitamin C function in the brain: vital role of the ascorbate transporter SVCT2. Free Radical Biology and Medicine. 2009 Mar 15;46(6):719-30.
  10. Padayatty SJ, Doppman JL, Chang R, Wang Y, Gill J, Papanicolaou DA, Levine M. Human adrenal glands secrete vitamin C in response to adrenocorticotrophic hormone. The American journal of clinical nutrition. 2007 Jul 1;86(1):145-9.
  11. The Linus Pauling Institute. http://lpi.oregonstate.edu/mic/minerals/zinc. Accessed 19 April 2017.
  12. Hojyo S, Fukada T. Roles of zinc signaling in the immune system. Journal of immunology research. 2016 Oct 31;2016.
  13. Hadwan MH, Almashhedy LA, Alsalman AR. Study of the effects of oral zinc supplementation on peroxynitrite levels, arginase activity and NO synthase activity in seminal plasma of Iraqi asthenospermic patients. Reproductive Biology and Endocrinology. 2014 Dec;12(1):1-8.
  14. Zhao J, Dong X, Hu X, Long Z, Wang L, Liu Q, Sun B, Wang Q, Wu Q, Li L. Zinc levels in seminal plasma and their correlation with male infertility: A systematic review and meta-analysis. Scientific reports. 2016 Mar 2;6(1):1-0.
  15. Cai C, Lin P, Zhu H, Ko JK, Hwang M, Tan T, Pan Z, Korichneva I, Ma J. Zinc binding to MG53 protein facilitates repair of injury to cell membranes. Journal of Biological Chemistry. 2015 May 29;290(22):13830-9.
  16. Lansdown AB, Mirastschijski U, Stubbs N, Scanlon E, Ågren MS. Zinc in wound healing: theoretical, experimental, and clinical aspects. Wound repair and regeneration. 2007 Jan;15(1):2-16.
  17. Bhatnagar S, Taneja S. Zinc and cognitive development. British journal of nutrition. 2001 May;85(S2):S139-45.
  18. Wegmüller R, Tay F, Zeder C, Brnić M, Hurrell RF. Zinc absorption by young adults from supplemental zinc citrate is comparable with that from zinc gluconate and higher than from zinc oxide. The Journal of nutrition. 2014 Feb 1;144(2):132-6.
  19. Ganesan S, Faris AN, Comstock AT, Wang Q, Nanua S, Hershenson MB, Sajjan US. Quercetin inhibits rhinovirus replication in vitro and in vivo. Antiviral research. 2012 Jun 1;94(3):258-71.
  20. Thapa M, Kim Y, Desper J, Chang KO, Hua DH. Synthesis and antiviral activity of substituted quercetins. Bioorganic & medicinal chemistry letters. 2012 Jan 1;22(1):353-6.
  21. Wu W, Li R, Li X, He J, Jiang S, Liu S, Yang J. Quercetin as an antiviral agent inhibits influenza A virus (IAV) entry. Viruses. 2015 Dec 25;8(1):6.
  22. Lu NT, Crespi CM, Liu NM, Vu JQ, Ahmadieh Y, Wu S, Lin S, McClune A, Durazo F, Saab S, Han S. A phase I dose escalation study demonstrates quercetin safety and explores potential for bioflavonoid antivirals in patients with chronic hepatitis C. Phytotherapy research. 2016 Jan;30(1):160-8.
  23. Lee M, Son M, Ryu E, Shin YS, Kim JG, Kang BW, Sung GH, Cho H, Kang H. Quercetin-induced apoptosis prevents EBV infection. Oncotarget. 2015 May 5;6(14):12603.
  24. Bischoff SC. Quercetin: potentials in the prevention and therapy of disease. Current Opinion in Clinical Nutrition & Metabolic Care. 2008 Nov 1;11(6):733-40.
  25. Imbalance A. Nutrients and botanicals for treatment of stress: adrenal fatigue, neurotransmitter imbalance, anxiety, and restless sleep. Altern Med Rev. 2009;14(2):114-40.
  26. McCarty MF. High-dose pyridoxine as an ‘anti-stress’ strategy. Medical Hypotheses. 2000 May 1;54(5):803-7.
  27. Baldewicz T, Goodkin K, Feaster DJ, Blaney NT, Kumar M, Kumar A, Shor-Posner G, Baum M. Plasma pyridoxine deficiency is related to increased psychological distress in recently bereaved homosexual men. Psychosomatic medicine. 1998 May 1;60(3):297-308.
  28. Wyatt KM, Dimmock PW, Jones PW, O'Brien PS. Efficacy of vitamin B-6 in the treatment of premenstrual syndrome: systematic review. Bmj. 1999 May 22;318(7195):1375-81.
  29. Tenaud I, Leroy S, Chebassier N, Dreno B. Zinc, copper and manganese enhanced keratinocyte migration through a functional modulation of keratinocyte integrins. Experimental dermatology. 2000 Dec;9(6):407-16.
  30. Higdon J, Drake VJ. http://lpi.oregonstate.edu/mic/minerals/manganese. Accessed 18 April 2017.
  31. Holley AK, Dhar SK, Xu Y, St Clair DK. Manganese superoxide dismutase: beyond life and death. Amino acids. 2012 Jan;42(1):139-58.
  32. Watts DL. Trace Elements and Other Essential Nutrients: clinical application of tissue mineral analysis, 6th Edn. Writers B L O C K, 2010, p 119.
  33. Baïz N, Chastang J, Ibanez G, Annesi‐Maesano I. Prenatal exposure to selenium may protect against wheezing in children by the age of 3. Immunity, Inflammation and Disease. 2017 Mar;5(1):37-44.
  34. Shaheen SO, Rutterford CM, Lewis SJ, Ring SM, Holloway JW, Golding J, Henderson AJ. Maternal selenium status in pregnancy, offspring glutathione peroxidase 4 genotype, and childhood asthma. Journal of Allergy and Clinical Immunology. 2015 Apr 1;135(4):1083-5.
  35. Ariaee N, Farid R, Shabestari F, Shabestari M, Azad FJ. Trace elements status in sera of patients with allergic asthma. Reports of biochemistry & molecular biology. 2016 Oct;5(1):20.
  36. Kasperczyk S, Dobrakowski M, Kasperczyk J, Romuk E, Prokopowicz A, Birkner E. The influence of β-carotene on homocysteine level and oxidative stress in lead-exposed workers. Med. Pr. 2014 Jan 1;65:309-16.
  37. Ben-Amotz A, Yatziv S, Sela M, Greenberg S, Rachmilevich B, Shwarzman M, Weshler ZE. Effect of natural b-carotene supplementation in children exposed to radiation from the Chernobyl accident. Radiation and Environmental Biophysics. 1998 Nov;37(3):187-93.
  38. Princen HM, van Poppel G, Vogelezang C, Buytenhek R, Kok FJ. Supplementation with vitamin E but not beta-carotene in vivo protects low density lipoprotein from lipid peroxidation in vitro. Effect of cigarette smoking. Arteriosclerosis and Thrombosis: A Journal of Vascular Biology. 1992 May;12(5):554-62.
  39. Maggini S, Beveridge S, Suter M. A combination of high-dose vitamin C plus zinc for the common cold. Journal of International Medical Research. 2012 Feb;40(1):28-42.
  40. Hemilä H, Chalker E. The effectiveness of high dose zinc acetate lozenges on various common cold symptoms: a meta-analysis. BMC family practice. 2015 Dec;16(1):1-1.
  41. Hemilä H, Petrus EJ, Fitzgerald JT, Prasad A. Zinc acetate lozenges for treating the common cold: an individual patient data meta‐analysis. British journal of clinical pharmacology. 2016 Nov;82(5):1393-8.
  42. Johnstone J, Roth DE, Guyatt G, Loeb M. Zinc for the treatment of the common cold: a systematic review and meta-analysis of randomized controlled trials. Cmaj. 2012 Jul 10;184(10):E551-61.
  43. Veverka DV, Wilson C, Martinez MA, Wenger R, Tamosuinas A. Use of zinc supplements to reduce upper respiratory infections in United States Air Force Academy cadets. Complementary Therapies in Clinical Practice. 2009 May 1;15(2):91-5.
  44. Rerksuppaphol S, Rerksuppaphol L. A randomized controlled trial of chelated zinc for prevention of the common cold in Thai school children. Paediatrics and international child health. 2013 Aug 1;33(3):145-50.
  45. Lassi ZS, Moin A, Bhutta ZA. Zinc supplementation for the prevention of pneumonia in children aged 2 months to 59 months. Cochrane Database of Systematic Reviews. 2016(12).
  46. Prasad AS, Beck FW, Bao B, Fitzgerald JT, Snell DC, Steinberg JD, Cardozo LJ. Zinc supplementation decreases incidence of infections in the elderly: effect of zinc on generation of cytokines and oxidative stress. The American journal of clinical nutrition. 2007 Mar 1;85(3):837-44.
  47. Hodkinson CF, Kelly M, Alexander HD, Bradbury I, Robson PJ, Bonham MP, O'Connor JM, Coudray C, Strain JJ, Wallace JM. Effect of zinc supplementation on the immune status of healthy older individuals aged 55–70 years: the ZENITH Study. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. 2007 Jun 1;62(6):598-608.
  48. Barnett JB, Dao MC, Hamer DH, Kandel R, Brandeis G, Wu D, Dallal GE, Jacques PF, Schreiber R, Kong E, Meydani SN. Effect of zinc supplementation on serum zinc concentration and T cell proliferation in nursing home elderly: a randomized, double-blind, placebo-controlled trial. The american journal of clinical nutrition. 2016 Mar 1;103(3):942-51.
  49. Costarelli L, Giacconi R, Malavolta M, Basso A, Piacenza F, DeMartiis M, Giannandrea E, Renieri C, Busco F, Galeazzi R, Mocchegiani E. Effects of zinc-fortified drinking skim milk (as functional food) on cytokine release and thymic hormone activity in very old persons: a pilot study. Age. 2014 Jun;36(3):1421-31.
  50. Kahmann L, Uciechowski P, Warmuth S, Malavolta M, Mocchegiani E, Rink L. Effect of improved zinc status on T helper cell activation and TH1/TH2 ratio in healthy elderly individuals. Biogerontology. 2006 Oct;7(5):429-35.
  51. Abdulhamid I, Beck FW, Millard S, Chen X, Prasad A. Effect of zinc supplementation on respiratory tract infections in children with cystic fibrosis. Pediatric pulmonology. 2008 Mar;43(3):281-7.
  52. Ahmad SM, Hossain MB, Monirujjaman M, Islam S, Huda M, Kabir Y, Raqib R, Lönnerdal BL. Maternal zinc supplementation improves hepatitis B antibody responses in infants but decreases plasma zinc level. European journal of nutrition. 2016 Aug;55(5):1823-9.
  53. Hughes DA, Wright AJ, Finglas PM, Peerless AC, Bailey AL, Astley SB, Pinder AC, Southon S. The effect of β-carotene supplementation on the immune function of blood monocytes from healthy male nonsmokers. Journal of Laboratory and Clinical Medicine. 1997 Mar 1;129(3):309-17.
  54. Taylor TV, Rimmer S, Day B, Butcher J, Dymock IW. Ascorbic acid supplementation in the treatment of pressure-sores. The Lancet. 1974 Sep 7;304(7880):544-6.
  55. ter Riet G, Kessels AG, Knipschild PG. Randomized clinical trial of ascorbic acid in the treatment of pressure ulcers. Journal of clinical epidemiology. 1995 Dec 1;48(12):1453-60.
  56. Ghanayem H. Towards evidence based emergency medicine: Best BETs from the Manchester Royal Infirmary. BET 3: Vitamin C in severe burns. Emergency Medicine Journal: EMJ. 2012 Dec 1;29(12):1017-8.
  57. Lauer AC, Groth N, Haag SF, Darvin ME, Lademann J, Meinke MC. Dose-dependent vitamin C uptake and radical scavenging activity in human skin measured with in vivo electron paramagnetic resonance spectroscopy. Skin pharmacology and physiology. 2013;26(3):147-54.
  58. Aurer-Kozelj J, Kralj-Klobucar N, Buzina R, Bacic M. The effect of ascorbic acid supplementation on periodontal tissue ultrastructure in subjects with progressive periodontitis. International Journal for Vitamin and Nutrition research. Internationale Zeitschrift fur Vitamin-und Ernahrungsforschung. Journal International de Vitaminologie et de Nutrition. 1982 Jan 1;52(3):333-41.
  59. Wilkinson EA, Hawke CI. Does oral zinc aid the healing of chronic leg ulcers?: A systematic literature review. Archives of Dermatology. 1998 Dec 1;134(12):1556-60.
  60. Momen‐Heravi M, Barahimi E, Razzaghi R, Bahmani F, Gilasi HR, Asemi Z. The effects of zinc supplementation on wound healing and metabolic status in patients with diabetic foot ulcer: a randomized, double‐blind, placebo‐controlled trial. Wound Repair and Regeneration. 2017 May;25(3):512-20.
  61. Pories W, Henzel J, Rob C, Strain W. Acceleration of wound healing in man with zinc sulphate given by mouth. The Lancet. 1967 Jan 21;289(7482):121-4.
  62. Hillstrom l, Pettersson l, Hellbe l, Kjellin a, Leczinsky cg, Nordwall c. Comparison of oral treatment with zinc sulphate and placebo in acne vulgaris. British Journal of Dermatology. 1977 Dec;97(6):679-84.
  63. Bae YS, Hill ND, Bibi Y, Dreiher J, Cohen AD. Innovative uses for zinc in dermatology. Dermatologic clinics. 2010 Jul 1;28(3):587-97.
  64. Gupta M, Mahajan VK, Mehta KS, Chauhan PS. Zinc therapy in dermatology: a review. Dermatology research and practice. 2014 Jul 10;2014.
  65. Dreno B, Amblard P, Agache P, Sirot S, Litoux P. Low doses of zinc gluconate for inflammatory acne. Acta Dermato-Venereologica. 1989 Jan 1;69(6):541-3.
  66. Dreno B, Moyse D, Alirezai M, Amblard P, Auffret N, Beylot C, Bodokh I, Chivot M, Daniel F, Humbert P, Meynadier J. Multicenter randomized comparative double-blind controlled clinical trial of the safety and efficacy of zinc gluconate versus minocycline hydrochloride in the treatment of inflammatory acne vulgaris. Dermatology. 2001;203(2):135-40.
  67. Thein DJ, Hurt WC. Lysine as a prophylactic agent in the treatment of recurrent herpes simplex labialis. Oral surgery, oral medicine, oral pathology. 1984 Dec 1;58(6):659-66.
  68. Milman N, Scheibel J, Jessen O. Lysine prophylaxis in recurrent herpes simplex labialis: a double-blind, controlled crossover study. Acta Dermato-venereologica. 1980 Jan 1;60(1):85-7.
  69. Griffith RS, Walsh DE, Myrmel KH, Thompson RW, Behforooz A. Success of L-lysine therapy in frequently recurrent herpes simplex infection. Dermatology. 1987;175(4):183-90.
  70. McCune MA, Perry HO, Muller SA, O'Fallon WM. Treatment of recurrent herpes simplex infections with L-lysine monohydrochloride. Cutis. 1984 Oct 1;34(4):366-73.
  71. Walsh DE, Griffith RS, Behforooz A. Subjective response to lysine in the therapy of herpes simplex. Journal of Antimicrobial Chemotherapy. 1983 Nov 1;12(5):489-96.
  72. Brody S, Preut R, Schommer K, Schürmeyer TH. A randomized controlled trial of high dose ascorbic acid for reduction of blood pressure, cortisol, and subjective responses to psychological stress. Psychopharmacology. 2002 Jan;159(3):319-24.
  73. Kallner A. Influence of vitamin C status on the urinary excretion of catecholamines in stress. Human nutrition. Clinical Nutrition. 1983 Dec 1;37(6):405-11.
  74. Akmal M, Qadri JQ, Al-Waili NS, Thangal S, Haq A, Saloom KY. Improvement in human semen quality after oral supplementation of vitamin C. Journal of medicinal food. 2006 Sep 1;9(3):440-2.
  75. Cyrus A, Kabir A, Goodarzi D, Moghimi M. The effect of adjuvant vitamin C after varicocele surgery on sperm quality and quantity in infertile men: a double blind placebo controlled clinical trial. International braz j urol. 2015 Mar;41:230-8.
  76. Rafiee B, Morowvat MH, Rahimi-Ghalati N. Comparing the effectiveness of dietary vitamin C and exercise interventions on fertility parameters in normal obese men. Urology journal. 2016 Apr 16;13(2):2635-9.
  77. Omu AE, Dashti H, Al-Othman S. Treatment of asthenozoospermia with zinc sulphate: andrological, immunological and obstetric outcome. European Journal of Obstetrics & Gynecology and Reproductive Biology. 1998 Aug 1;79(2):179-84.
  78. Safarinejad MR, Safarinejad S. Efficacy of selenium and/or N-acetyl-cysteine for improving semen parameters in infertile men: a double-blind, placebo controlled, randomized study. The Journal of urology. 2009 Feb;181(2):741-51.
  79. Scott R, MacPherson A, Yates RW, Hussain B, Dixon J. The effect of oral selenium supplementation on human sperm motility. British journal of urology. 1998 Jul 1;82(1):76-80.
  80. Young B, Ott L, Kasarskis E, Rapp R, Moles KA, Dempsey RJ, Tibbs PA, Kryscio R, Mcclain CR. Zinc supplementation is associated with improved neurologic recovery rate and visceral protein levels of patients with severe closed head injury. Journal of neurotrauma. 1996 Jan;13(1):25-34.
  81. de Moura JE, de Moura EN, Alves CX, de Lima Vale SH, Dantas MM, de Araújo Silva A, das Graças Almeida M, Leite LD, Brandão-Neto J. Oral zinc supplementation may improve cognitive function in schoolchildren. Biological trace element research. 2013 Oct;155(1):23-8.
  82. Solati Z, Jazayeri S, Tehrani-Doost M, Mahmoodianfard S, Gohari MR. Zinc monotherapy increases serum brain-derived neurotrophic factor (BDNF) levels and decreases depressive symptoms in overweight or obese subjects: a double-blind, randomized, placebo-controlled trial. Nutritional neuroscience. 2015 May 1;18(4):162-8.
  83. Nowak G, Siwek M, Dudek D, Ziêba A, Pilc A. Effect of zinc supplementation on antidepressant therapy in unipolar depression: a preliminary placebo-controlled study. Polish journal of pharmacology. 2003 Dec;55(6):1143-8.
  84. Ranjbar E, Shams J, Sabetkasaei M, M-Shirazi M, Rashidkhani B, Mostafavi A, Bornak E, Nasrollahzadeh J. Effects of zinc supplementation on efficacy of antidepressant therapy, inflammatory cytokines, and brain-derived neurotrophic factor in patients with major depression. Nutritional neuroscience. 2014 Feb 1;17(2):65-71.
  85. Sawada T, Yokoi K. Effect of zinc supplementation on mood states in young women: a pilot study. European journal of clinical nutrition. 2010 Mar;64(3):331-3.
  86. McGinnis WR, Audhya T, Walsh WJ, Jackson JA, McLaren-Howard J, Lewis A, Lauda PH, Bibus DM, Jurnak F, Lietha R, Hoffer A. Discerning the mauve factor, Part 1. Alternative therapies in health and medicine. 2008 Mar 1;14(2):40-51.
  87. Jamilian M, Foroozanfard F, Bahmani F, Talaee R, Monavari M, Asemi Z. Effects of zinc supplementation on endocrine outcomes in women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial. Biological trace element research. 2016 Apr;170(2):271-8.
  88. Jaworski K, Walecka I, Rudnicka L, Gnatowski M, Kosior DA. Cutaneous adverse reactions of amiodarone. Medical science monitor: international medical journal of experimental and clinical research. 2014;20:2369.
  89. Bailey RL, Gahche JJ, Lentino CV, Dwyer JT, Engel JS, Thomas PR, et al. Dietary supplement use in the United States, 2003-2006. J Nutr 2011;141:261-6.
  90. Mehta R, Reilly JJ. Manganese Levels in a Jaundiced Long‐Term Total Parenteral Nutrition Patient: Potentiation of Haloperidol Toxicity?: Case Report and Literature Review. Journal of Parenteral and Enteral Nutrition. 1990 Jul;14(4):428-30.
  91. Choi JS, Choi BC, Choi KE. Effect of quercetin on the pharmacokinetics of oral cyclosporine. American journal of health-system pharmacy. 2004 Nov 15;61(22):2406-9.



logo

Your one stop destination for education and clinical tools, driven by our purpose to inspire people to live better lives through natural healthcare.

Customer Care or Clinical Support

1300 654 336

or visit www.myintegria.com

© 2025, Integria is a registered trademark of Integria Healthcare (Australia) Pty Ltd

Terms of Use | Privacy | Policies