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References - Clinical Applications of Magnesium Orotate

  1. National Center for Biotechnology Information. PubChem Compound Database. Magnesium orotate. Available at: https://pubchem.ncbi.nlm.nih.gov/compound/Magnesium-orotate
  2. Friend, J. The Discovery of Magnesium. Nature. 1950; 166, 615.
  3. Löffler M, Carrey EA, Zameitat E. Orotate (orotic acid): An essential and versatile molecule. Nucleosides Nucleotides Nucleic Acids. 2016 Dec;35(10-12):566-577.
  4. Braun L. Cohen M. Herbs & Natural Supplements - An evidence-based guide. 4th ed. Volume 2. Sydney: Churchill Livingstone; 2015.
  5. Rosenfeldt FL. Metabolic supplementation with orotic acid and magnesium orotate. Cardiovasc Drugs Ther. 1998 Sep;12 Suppl 2:147-52.
  6. Rosenfeldt FL, Richards SM, Lin Z, Pepe S, Conyers RA. Mechanism of cardioprotective effect of orotic acid. Cardiovasc Drugs Ther. 1998 Sep;12 Suppl 2:159-70.
  7. Zeana C. Magnesium orotate in myocardial and neuronal protection. Rom J Intern Med. 1999 Jan-Mar;37(1):91-7.
  8. Classen HG. Magnesium orotate--experimental and clinical evidence. Rom J Intern Med. 2004;42(3):491-501.
  9. Geiss KR, Stergiou N, Jester, Neuenfeld HU, Jester HG. Effects of magnesium orotate on exercise tolerance in patients with coronary heart disease. Cardiovasc Drugs Ther. 1998 Sep;12 Suppl 2:153-6.
  10. Gröber U, Schmidt J, Kisters K. Magnesium in Prevention and Therapy. Nutrients. 2015 Sep 23;7(9):8199-226.
  11. Volpe SL. Magnesium in disease prevention and overall health. Adv Nutr. 2013 May 1;4(3):378S-83S. doi: 10.3945/an.112.003483.
  12. Natural Medicines. Magnesium Monograph. Therapeutic Research Centre. 2020. Available from: https://naturalmedicines.therapeuticresearch.com/
  13. Sontia B, Touyz RM. Role of magnesium in hypertension. Arch Biochem Biophys. 2007 Feb 1;458(1):33-9.
  14. Zhang X et al. Effects of Magnesium Supplementation on Blood Pressure. A Meta-Analysis of Randomized Double-Blind Placebo-Controlled Trials. Hypertension. 2016;68:324–333.
  15. Baker WL. Treating arrhythmias with adjunctive magnesium: identifying future research directions. Eur Heart J Cardiovasc Pharmacother. 2017 Apr 1;3(2):108-117.
  16. Blancquaert L, Vervaet C, Derave W. Predicting and Testing Bioavailability of Magnesium Supplements. Nutrients. 2019 Jul 20;11(7):1663.
  17. Gropper SS & Smith JL. Advanced Nutrition and Human Metabolism. 6th edition. Wadsworth CENGAGE Learning, Australia, 2013.
  18. Natural Medicines. Potassium Monograph. Therapeutic Research Centre. 2020. Available from: https://naturalmedicines.therapeuticresearch.com/
  19. Natural Medicines. Vitamin B6 Monograph. Therapeutic Research Centre. 2020. Available from: https://naturalmedicines.therapeuticresearch.com/
  20. Stepura OB, Martynow AI. Magnesium orotate in severe congestive heart failure (MACH). Int J Cardiol. 2009 May 1;134(1):145-7.
  21. Martynov AI, Stepura OB, Shekhter AB, Mel'nik OO, Pak LS, Ushakova TI. Novye podkhody k lecheniiu bol'nykh s idiopaticheskim prolabirovaniem mitral'nogo klapana [New approaches to the treatment of patients with idiopathic mitral valve prolapse]. Ter Arkh. 2000;72(9):67-70. [Russian].
  22. Branea I, Gaiţă D, Drăgulescu I, Socoteanu I, Luca C, Mancaş S, et al. Assessment of treatment with orotate magnesium in early postoperative period of patients with cardiac insufficiency and coronary artery by-pass grafts (ATOMIC). Rom J Intern Med. 1999 Jul-Sep;37(3):287-96.
  23. Leong JY, van der Merwe J, Pepe S, Bailey M, Perkins A, Lymbury R, Esmore D, Marasco S, Rosenfeldt F. Perioperative metabolic therapy improves redox status and outcomes in cardiac surgery patients: a randomised trial. Heart Lung Circ. 2010 Oct;19(10):584-91.
  24. Mirica SN, Duicu OM, Trancota SL, Fira-Mladinescu O, Angoulvant D, Muntean DM. Magnesium orotate elicits acute cardioprotection at reperfusion in isolated and in vivo rat hearts. Can J Physiol Pharmacol. 2013 Feb;91(2):108-15
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